Evidence map›Paper›PMID 33144666›Full record

ArticleCommunications biology2020

Embryonic liver developmental trajectory revealed by single-cell RNA sequencing in the Foxa2

Tianhao Mu, Liqin Xu, Yu Zhong, Xinyu Liu, Zhikun Zhao, Chaoben Huang, Xiaofeng Lan, Chengchen Lufei, Yi Zhou, Yixun Su and 13 more

Abstract read
In one paragraph

Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Review
  2. Article
  3. Toward Computationally Complete Spatial Omics.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Primitive Hepatoblasts Driving Early Liver Development.bioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Generation ofRegenerative therapy · 2024
    Review
  18. Fetal liver development and implications for liver disease pathogenesis.Nature reviews. Gastroenterology & hepatology · 2023
    Review
  19. Article
  20. mNature metabolism · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Tianhao MuDepartment of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore, 119615, Singapore.ORCID 0000-0003-0177-7121
Liqin XuBGI-Shenzhen, 518033, Shenzhen, China.ORCID 0000-0003-3377-3707
Yu ZhongBGI-Shenzhen, 518033, Shenzhen, China.ORCID 0000-0001-6902-2732
Xinyu LiuGenEros Biopharma, 310018, Hangzhou, China.
Zhikun ZhaoBGI-Shenzhen, 518033, Shenzhen, China.
Chaoben HuangDepartment of Biology, Southern University of Science and Technology, 518055, Shenzhen, China.
Xiaofeng LanDepartment of Biology, Southern University of Science and Technology, 518055, Shenzhen, China.
Chengchen LufeiGenEros Biopharma, 310018, Hangzhou, China.
Yi ZhouGenEros Biopharma, 310018, Hangzhou, China.
Yixun SuDepartment of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore, 119615, Singapore.ORCID 0000-0001-8215-4270
Luang XuCancer Science Institute of Singapore, YLL School of Medicine, National University of Singapore, Singapore, 117599, Singapore.
Miaomiao JiangBGI-Shenzhen, 518033, Shenzhen, China.
Hongpo ZhouBGI-Shenzhen, 518033, Shenzhen, China.
Xinxin LinBGI-Shenzhen, 518033, Shenzhen, China.
Liang WuBGI-Shenzhen, 518033, Shenzhen, China.
Siqi PengBGI-Shenzhen, 518033, Shenzhen, China.
Shiping LiuBGI-Shenzhen, 518033, Shenzhen, China.ORCID 0000-0003-0019-619X
Susanne BrixDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Soltofts Plads, 2800, Kongens Lyngby, Denmark.ORCID 0000-0001-8951-6705
Michael DeanLaboratory of Translational Genomics, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Gaithersburg, MD, USA.ORCID 0000-0003-2234-0631
Norris R DunnEndodermal Development and Differentiation Laboratory, Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 138672, Singapore.ORCID 0000-0002-6259-2975
Kenneth S ZaretInstitute for Regenerative Medicine, University of Pennsylvania, Perelman School of Medicine, Smilow Center for Translation Research, Philadelphia, PA, 19104, USA.ORCID 0000-0001-8932-3145
Xin-Yuan FuDepartment of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore, 119615, Singapore. bchfxy@nus.edu.sg.ORCID 0000-0002-3199-4269
Yong HouBGI-Shenzhen, 518033, Shenzhen, China. houyong@genomics.cn.ORCID 0000-0002-0420-0726

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The liver and gallbladder are among the most important internal organs derived from the endoderm, yet the development of the liver and gallbladder in the early embryonic stages is not fully understood. Using a transgenic Foxa2

Indexed as

AnimalsCells, CulturedGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsHepatocyte Nuclear Factor 3-betaLiverMiceSequence Analysis, RNASingle-Cell Analysisenhanced green fluorescent proteinFoxa2 protein, mouseGreen Fluorescent ProteinsHepatocyte Nuclear Factor 3-beta

Identifiers

PMID33144666
PMCPMC7642341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.