Evidence map›Paper›PMID 33144618›Full record

ArticleScientific reports2020

Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival.

Kinnosuke Yahiro, Kohei Ogura, Yoshiyuki Goto, Sunao Iyoda, Tatsuya Kobayashi, Hiroki Takeuchi, Makoto Ohnishi, Joel Moss

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Kinnosuke YahiroDepartment of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan. yahirok@faculty.chiba-u.jp.
Kohei OguraAdvanced Health Care Science Research Unit, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, 920-0942, Japan.
Yoshiyuki GotoDivision of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, 260-8670, Japan.
Sunao IyodaDepartment of Bacteriology I, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.
Tatsuya KobayashiReproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Hiroki TakeuchiClinical Laboratory, University of Tsukuba Hospital, Tsukuba, 305-8576, Japan.
Makoto OhnishiDepartment of Bacteriology I, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.
Joel MossPulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892-1590, USA.
Chiba University · JPNational Institute of Infectious Diseases · JPJapan Agency for Medical Research and Development · JPKanazawa University · JPNational Heart Lung and Blood Institute · USUniversity of Tsukuba Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shiga-toxigenic Escherichia coli (STEC) infection causes severe bloody diarrhea, renal failure, and hemolytic uremic syndrome. Recent studies showed global increases in Locus for Enterocyte Effacement (LEE)-negative STEC infection. Some LEE-negative STEC produce Subtilase cytotoxin (SubAB), which cleaves endoplasmic reticulum (ER) chaperone protein BiP, inducing ER stress and apoptotic cell death. In this study, we report that SubAB induces expression of a novel form of Lipocalin-2 (LCN2), and describe its biological activity and effects on apoptotic cell death. SubAB induced expression of a novel LCN2, which was regulated by PRKR-like endoplasmic reticulum kinase via the C/EBP homologous protein pathway. SubAB-induced novel-sized LCN2 was not secreted into the culture supernatant. Increased intracellular iron level by addition of holo-transferrin or FeCl

Indexed as

Cell BiologyCommunicable DiseasesEscherichia coli ProteinsGlycomicsLipocalin-2Shiga-Toxigenic Escherichia coliSubtilisinsEscherichia coli ProteinsLipocalin-2subtilase cytotoxin, E coliSubtilisins

Identifiers

PMID33144618
PMCPMC7609767
OpenAlexW3097054663

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.