ArticleNature communications2020
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.
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In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
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82citing papers in PubMed, 8 pooled it
10.0field-weighted citation impact, top 1% of its field
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Who cites it
82 citing papers in PubMed, 8 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Does illicit drug use increase stroke risk? A systematic review, meta-analyses, and Mendelian randomization analysis.International journal of stroke : official journal of the International Stroke Society · 2026Pooled it
- Genome-wide meta-analyses of cross substance use disorders in diverse populations.Molecular psychiatry · 2026Pooled it
- Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.Nature human behaviour · 2024Pooled it
- Loci on chromosome 20 interact with rs16969968 to influence cigarettes per day in European ancestry individuals.Drug and alcohol dependence · 2024Pooled it
- Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.Nature genetics · 2023Pooled it
- A Systematic Review of Genetic Polymorphisms Associated with Bipolar Disorder Comorbid to Substance Abuse.Genes · 2022Pooled it
- Pooled it
- Analysis of genetic and clinical factors associated with buprenorphine response.Drug and alcohol dependence · 2021Pooled it
- Combining neuroimaging and brain stimulation to test alternative causal pathways for nicotine addiction in schizophrenia.Brain stimulationTrial
- Genetic Basis of Tobacco Use Disorder.Genes · 2026Review
- Indirect Genetic Effects on Alcohol Use Disorder and Nicotine Dependence.medRxiv : the preprint server for health sciences · 2026Article
- Comorbidity and Familial Aggregation of Mood Disorders and Cigarette Smoking in a Controlled Family Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Rare coding variants in CHRNB3 associate with reduced daily cigarette smoking across ancestries.Nature communications · 2026Article
- Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis.BMC medicine · 2026Article
- ADHD-anchored partitioning of non-small cell lung cancer genetic covariance identifiesFrontiers in immunology · 2026Article
- Article
- Shared genetic architecture of smoking dependence and Crohn's disease: A cross-trait analysis of GWAS summary statistics.Tobacco induced diseases · 2026Article
- Long-read whole-genome sequencing of SHR rat substrains with distinct substance use phenotypes.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Review
- Is tobacco dependence a moderator of psychiatric symptom severity and caregiver abuse in rural families of patients with severe mental disorders?Psychological medicine · 2025Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 20 institutions in 5 countries.
Bryan C QuachGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, 27709, USA.ORCID 0000-0002-1094-3104
Michael J BrayDepartment of Psychiatry, Washington University, St. Louis, MO, 63130, USA.
Nathan C GaddisGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, 27709, USA.
Mengzhen LiuDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA.ORCID 0000-0001-6550-6959
Teemu PalviainenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290, Helsinki, Finland.ORCID 0000-0002-7847-8384
Camelia C MinicaDepartment of Biological Psychology, Vrije Universiteit, 1081 BT, Amsterdam, The Netherlands.ORCID 0000-0001-7140-8167
Stephanie ZellersDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA.ORCID 0000-0001-8927-3483
Richard ShervaDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02118, USA.
Fazil AlievDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, 23284, USA.ORCID 0000-0001-8357-4699
Michael NothnagelCologne Center for Genomics, University of Cologne, 50931, Köln, Germany.
Kendra A YoungDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Jesse A MarksGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, 27709, USA.ORCID 0000-0002-8159-3594
Hannah YoungDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA.ORCID 0000-0002-4248-9612
Megan U CarnesGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, 27709, USA.
Yuelong GuoGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, 27709, USA.ORCID 0000-0003-1287-1906
Alex WaldropGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, 27709, USA.ORCID 0000-0002-4502-7894
Nancy Y A SeyDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.ORCID 0000-0001-8762-7401
Maria T LandiGenetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, 20892, USA.ORCID 0000-0003-4507-329X
Daniel W McNeilDepartment of Psychology, West Virginia University, Morgantown, WV, 26505, USA.
Dmitriy DrichelCologne Center for Genomics, University of Cologne, 50931, Köln, Germany.ORCID 0000-0001-5978-3458
Lindsay A FarrerDepartment of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, 02118, USA.
Christina A MarkunasGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, 27709, USA.
Jacqueline M VinkBehavioural Science Institute, Radboud University, 6500 HE, Nijmegen, The Netherlands.
Jouke-Jan HottengaDepartment of Biological Psychology, Vrije Universiteit, 1081 BT, Amsterdam, The Netherlands.ORCID 0000-0002-5668-2368
William G IaconoDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA.
Henry R KranzlerDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.ORCID 0000-0002-1018-0450
Nancy L SacconeDepartment of Genetics, Washington University, St. Louis, MO, 63130, USA.ORCID 0000-0002-4710-3926
Michael C NealeVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Pamela MaddenDepartment of Psychiatry, Washington University, St. Louis, MO, 63130, USA.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 68159, Mannheim, Germany.ORCID 0000-0002-5236-6149
Mary L MarazitaCenter for Craniofacial and Dental Genetics, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA.ORCID 0000-0002-2648-2832
Matthew McGueDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA.
Hyejung WonDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.ORCID 0000-0003-3651-0566
Georg WintererExperimental & Clinical Research Center, Department of Anesthesiology and Operative Intensive Care Medicine, Charité - University Medicine Berlin, 10117, Berlin, Germany.
Richard GruczaDepartments of Family and Community Medicine and Health and Clinical Outcomes Research, Saint Louis University, St. Louis, MO, 63130, USA.
Danielle M DickDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, 23284, USA.ORCID 0000-0002-1636-893X
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, 06511, USA.ORCID 0000-0002-4067-1859
Neil E CaporasoOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD, 20892, USA.
Timothy B BakerCenter for Tobacco Research and Intervention, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53726, USA.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit, 1081 BT, Amsterdam, The Netherlands.ORCID 0000-0002-7099-7972
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00290, Helsinki, Finland.ORCID 0000-0002-3716-2455
John E HokansonDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Scott VriezeDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, 55455, USA.ORCID 0000-0003-3861-7930
Laura J BierutDepartment of Psychiatry, Washington University, St. Louis, MO, 63130, USA.ORCID 0000-0002-9952-4810
Eric O JohnsonGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, 27709, USA.ORCID 0000-0002-8870-1949
Dana B HancockGenOmics, Bioinformatics, and Translational Research Center, Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, 27709, USA. dhancock@rti.org.ORCID 0000-0003-2240-3604
RTI International · USUniversity of Minnesota · USWashington University in St. Louis · USVrije Universiteit Amsterdam · NLBoston University · USUnited States Department of Health and Human Services · USUniversity of Cologne · DEUniversity of Colorado Anschutz Medical Campus · USUniversity of Helsinki · FIUniversity of North Carolina at Chapel Hill · USVirginia Commonwealth University · USCharité - Universitätsmedizin Berlin · DEHeidelberg University · DEKarabük University · TRPhiladelphia VA Medical Center · USRadboud University Nijmegen · NLSaint Louis University · USUniversity of Pittsburgh · USUniversity of Wisconsin–Madison · USWest Virginia University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MWest Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Rayjean J. Hung · 2017 to 2026
$23.7MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MThe Effects of Cannabis Legalization and Persistent Use: A Longitudinal Study of Two Twin CohortsR01DA042755 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Jarrod Martin Ellingson, SOO H RHEE · 2017 to 2026
$9.9MGenes contributing to nicotine dependence in humansR01DA017932 · NIDA · DECODE GENETICS, INC. · PI STEFANSSON, KARI · 2005 to 2015
$9.6MAdolescent drinking and midlife outcomes: A prospective cotwin control studyR37AA009367 · NIAAA · UNIVERSITY OF MINNESOTA · PI MCGUE, MATTHEW K. · 2016 to 2024
$5.4MIntegrating Epigenomics in Human Brain and Genomics of Nicotine DependenceR01DA042090 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI HANCOCK, DANA B · 2016 to 2020
$3.5MDeep Sequencing, Phenotyping, and Imputation in Large-Scale Biobanks: A Novel and Cost-Effective Framework to Identify Rare Mutations Associated with AddictionR01DA044283 · NIDA · UNIVERSITY OF MINNESOTA · PI ALBERT, FRANK WOLFGANG, VRIEZE, SCOTT IAN · 2019 to 2024
$3.2MNicotine Dependence to Smoking Cessation: Sequencing Common and Rare VariantsR01DA036583 · NIDA · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2014 to 2017
$3.0MGenetic Association Meta-Analyses of Smoking and Drinking for the Sequencing AgeR01DA037904 · NIDA · UNIVERSITY OF MINNESOTA · PI VRIEZE, SCOTT IAN · 2015 to 2019
$2.4MDeciphering Cell-type Specific Regulatory Landscape in Human BrainDP2MH122403 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WON, HYEJUNG · 2019 to 2019
$2.3MMedical Research Council MC_PC_17228Medical Research Council MC_QA137853NCATS NIH HHS UL1 TR001863NCI NIH HHS U19 CA203654NHLBI NIH HHS U01 HL089856NIAAA NIH HHS R37 AA009367NIDA NIH HHS R01 DA017932NIDA NIH HHS R01 DA035825NIDA NIH HHS R01 DA036583NIDA NIH HHS R01 DA037904NIDA NIH HHS R01 DA042090NIDA NIH HHS R01 DA042195NIDA NIH HHS R01 DA042755NIDA NIH HHS R01 DA044283NIDA NIH HHS R21 DA046188NIDA NIH HHS R21 DA051921NIGMS NIH HHS U54 GM104942NIMH NIH HHS DP2 MH122403NIMH NIH HHS R00 MH113823
Abstract
Cigarette smoking is the leading cause of preventable morbidity and mortality. Genetic variation contributes to initiation, regular smoking, nicotine dependence, and cessation. We present a Fagerström Test for Nicotine Dependence (FTND)-based genome-wide association study in 58,000 European or African ancestry smokers. We observe five genome-wide significant loci, including previously unreported loci MAGI2/GNAI1 (rs2714700) and TENM2 (rs1862416), and extend loci reported for other smoking traits to nicotine dependence. Using the heaviness of smoking index from UK Biobank (N = 33,791), rs2714700 is consistently associated; rs1862416 is not associated, likely reflecting nicotine dependence features not captured by the heaviness of smoking index. Both variants influence nearby gene expression (rs2714700/MAGI2-AS3 in hippocampus; rs1862416/TENM2 in lung), and expression of genes spanning nicotine dependence-associated variants is enriched in cerebellum. Nicotine dependence (SNP-based heritability = 8.6%) is genetically correlated with 18 other smoking traits (r
Indexed as
Genetic Predisposition to DiseaseQuantitative Trait, HeritableGenetic LociGenome-Wide Association StudyHumansInheritance PatternsLinkage DisequilibriumMeta-Analysis as TopicMolecular Sequence AnnotationPhenotypePolymorphism, Single NucleotideTobacco Use Disorder
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