ArticleKorean journal of orthodontics2020
Antifibrotic effects of sulforaphane treatment on gingival elasticity reduces orthodontic relapse after rotational tooth movement in beagle dogs.
Article in Korean journal of orthodontics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Mesenchymal stem cell-derived exosomes: a potential cell-free therapy for orthodontic tooth stability management.Stem cell research & therapy · 2024Review
- The effects of fulvic acids and low-level laser therapy on orthodontic retention in rats.BMC oral health · 2024Article
- The Emerging Role of MMP12 in the Oral Environment.International journal of molecular sciences · 2023Review
- Level of knowledge about metalloproteinases in dental students close to graduate from three universities in Peruvian capital city.European journal of dental education : official journal of the Association for Dental Education in Europe · 2022Observational
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
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Abstract
objectiveIncreased gingival elasticity has been implicated as the cause of relapse following orthodontic rotational tooth movement and approaches to reduce relapse are limited. This study aimed to investigate the effects of sulforaphane (SFN), an inhibitor of osteoclastogenesis, on gene expression in gingival fibroblasts and relapse after rotational tooth movement in beagle dogs.
methodsThe lower lateral incisors of five beagle dogs were rotated. SFN or dimethylsulfoxide (DMSO) were injected into the supra-alveolar gingiva of the experimental and control group, respectively, and the effect of SFN on relapse tendency was evaluated. Changes in mRNA expression of extracellular matrix components associated with gingival elasticity in beagles were investigated by real-time polymerase chain reaction. Morphology and arrangement of collagen fibers were observed on Masson's trichrome staining of buccal gingival tissues of experimental and control teeth.
resultsSFN reduced the amount and percentage of relapse of orthodontic rotation. It also decreased the gene expression of lysyl oxidase and increased the gene expression of matrix metalloproteinase (
conclusionsOur findings demonstrated that SFN treatment may be a promising pharmacologic approach to prevent orthodontic rotational relapse caused by increased gingival elasticity of rotated teeth in beagle dogs.
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