Evidence map›Paper›PMID 33144481›Full record

Trial reportIn vivo (Athens, Greece)

Changing Patterns of Distant Metastasis in Patients With Lower Rectal Cancer Undergoing Intraoperative Radiotherapy.

Tadahiko Masaki, Hiroyoshi Matsuoka, Tomokazu Kishiki, Koichiro Kojima, Ayako Tonari, Nobuyoshi Aso, Ayumi Beniya, Aiko Iioka, Takashi Wakamatsu, Eiji Sunami

Open access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Tadahiko MasakiDepartment of Surgery, Kyorin University, Tokyo, Japan masaki@ks.kyorin-u.ac.jp.
Hiroyoshi MatsuokaDepartment of Surgery, Kyorin University, Tokyo, Japan.
Tomokazu KishikiDepartment of Surgery, Kyorin University, Tokyo, Japan.
Koichiro KojimaDepartment of Surgery, Kyorin University, Tokyo, Japan.
Ayako TonariDepartment of Radiation Oncology, Kyorin University, Tokyo, Japan.
Nobuyoshi AsoDepartment of Surgery, Kyorin University, Tokyo, Japan.
Ayumi BeniyaDepartment of Surgery, Kyorin University, Tokyo, Japan.
Aiko IiokaDepartment of Surgery, Kyorin University, Tokyo, Japan.
Takashi WakamatsuDepartment of Surgery, Kyorin University, Tokyo, Japan.
Eiji SunamiDepartment of Surgery, Kyorin University, Tokyo, Japan.
Kyorin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimLocal radiotherapy for primary tumors may increase the incidence of distant metastasis. However, the patterns of target organs have not been clarified yet. PATIENTS AND

methodsIn our randomized controlled trial examining the oncological efficacy of intraoperative radiotherapy (IORT) for advanced lower rectal cancer, the details of the metastatic organs were evaluated.

resultsIn the IORT group (38 patients), 2 patients had metastasis in the liver and lung simultaneously, 9 in the liver, and 4 in the lung. In the control group (38 patients), 3 had metastasis in the lung, and 2 in the liver. The IORT group tended to have liver metastases more frequently (p=0.058). Among patients with liver metastases, distant metastasis-free intervals were significantly shorter in the IORT group, however, no significant difference was observed among patients with lung metastases.

conclusionAfter curative rectal cancer surgery with IORT, liver metastasis may be increased and accelerated.

Indexed as

Rectal NeoplasmsCombined Modality TherapyHumansIntraoperative PeriodNeoplasm Recurrence, LocalPostoperative ComplicationsRectumdistant metastasisintraoperative radiotherapyLower rectal cancer

Identifiers

PMID33144481
PMCPMC7811602
OpenAlexW3097833367

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.