Evidence map›Paper›PMID 33144435›Full record

ArticleIn vivo (Athens, Greece)

Cocaine Reduces Ciliary Beat Frequency of Human Nasal Epithelial Cells.

Alexander Nastev, J Ulrich Sommer, Wieland Behr, Boris A Stuck, C Emika Mueller, Angela Schell, Benedikt Kramer, Daniel Haeussler, Karl Hoermann, Richard Birk

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Alexander NastevDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
J Ulrich SommerDepartment of Otorhinolaryngology, Head and Neck Surgery, Helios University Hospital Wuppertal, Wuppertal, Germany.
Wieland BehrDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
Boris A StuckDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
C Emika MuellerDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
Angela SchellDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim Medical Faculty, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
Benedikt KramerDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim Medical Faculty, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
Daniel HaeusslerDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim Medical Faculty, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
Karl HoermannDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Mannheim Medical Faculty, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.
Richard BirkDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany richard.birk@staff.uni-marburg.de.
Philipps University of Marburg · DEHeidelberg University · DEHelios Universitätsklinikum Wuppertal · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimCocaine is a widely used recreational drug and is known for its nasal complications including epithelial, cartilage and bone damage. The aim of the study was to analyze the impact of cocaine on ciliary beat frequency (CBF) of human nasal epithelial cells and therefore better understand its side effects on nasal mucosa. MATERIALS AND

methodsNasal epithelial cells of 21 healthy subjects were harvested and exposed in vitro to cocaine hydrochloride solutions ranging from 0.875% to 7%. High-speed video footage was acquired with phase contrast microscopy and CBF was analyzed with Sissons-Ammons Video Analysis (SAVA) software.

resultsAll tested concentrations led to a significant reduction in CBF compared to the control. Effects increased over time and with concentration. A mechanical inhibition of cilia by cocaine crystals was also observed.

conclusionWe assume that CBF reduction is part of the pathomechanism leading to nasal complications in cocaine abuse. Considering these results, clinical usage of cocaine should be critically evaluated and restricted to select cases only.

Indexed as

CocaineCell CountCiliaEpithelial CellsHumansNasal MucosaCocaineciliary beat frequency (CBF)Cocainehuman nasal epithelial cells

Identifiers

PMID33144435
PMCPMC7811604
OpenAlexW3096389000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.