Evidence map›Paper›PMID 33144411›Full record

SynthesisIn vivo (Athens, Greece)

IGF Bioregulation System in Benign and Malignant Thyroid Nodular Disease: A Systematic Review.

Apostolos Karagiannis, Eva Kassi, Antonios Chatzigeorgiou, Michael Koutsilieris

Open access · diamondAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Height, Autoimmune Thyroid Disease, and Thyroid Cancer: A Mendelian Randomization Study.Thyroid : official journal of the American Thyroid Association · 2023
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Apostolos KaragiannisDepartment of Physiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
Eva KassiDepartment of Biological Chemistry, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
Antonios ChatzigeorgiouDepartment of Physiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
Michael KoutsilierisDepartment of Physiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece mkoutsil@med.uoa.gr.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThe insulin-like growth factor bioregulation system is implicated in cancer biology. Herein, we aim to review the evidence on the expression of the insulin-like growth factor 1 and 2 (IGF1 and IGF2), their receptors (IGF-Rs) and IGF-binding proteins (IGFBPs) in thyroid tissue and their possible association with benign and malignant thyroid nodular diseases. MATERIALS AND

methodsWe systematically reviewed Pubmed and Scopus databases up to May 2020. A total of 375 articles were retrieved and analyzed.

resultsAmong 375 articles, 45 were included in this systematic review study. IGF1 was investigated in 31 studies, IGF2 in 1, IGF1 receptor in 15 and IGF-binding proteins in 13 articles. IGF1 expression in humans was dependent on the number and compound of benign nodules as well as the method of measurement. In differentiated thyroid carcinoma, a positive correlation between IGF1 and immunohistological stage was documented in some studies while in others only a positive trend was observed. IGF-1R and IGFBPs expression was higher in malignant rather than benign lesions. There was only a positive trend for increased IGF2 expression in malignancy, while IGFBPs were in most studies statistically increased in various cancer types compared to benign nodular disease.

conclusionThe present data demonstrate that in most studies there is statistically positive expression of IGF-1 and less of IGF-2 in thyroid cancer compared to normal thyroid tissue.

Indexed as

Insulin-Like Growth Factor IThyroid NeoplasmsHumansInsulin-Like Growth Factor Binding ProteinsPhosphorylationReceptor, IGF Type 1Signal TransductionInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IReceptor, IGF Type 1Insulin-like growth factorsthyroid cancerthyroid nodule

Identifiers

PMID33144411
PMCPMC7811675
OpenAlexW3096460788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.