Evidence map›Paper›PMID 33144375›Full record

ArticlemBio2020

Rawlings Datir, Steven Kemp, Kate El Bouzidi, Petra Mlchocova, Richard Goldstein, Judy Breuer, Greg J Towers, Clare Jolly, Miguel E Quiñones-Mateu, Patrick S Dakum and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. HIV-1 mutants expressing B cell clonogenic matrix protein p17 variants are increasing their prevalence worldwide.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 5 countries.

Rawlings DatirUniversity College London, London, United Kingdom.
Steven KempUniversity College London, London, United Kingdom.
Kate El BouzidiUniversity College London, London, United Kingdom.
Petra MlchocovaDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Richard GoldsteinUniversity College London, London, United Kingdom.ORCID 0000-0001-5148-4672
Judy BreuerUniversity College London, London, United Kingdom.
Greg J TowersUniversity College London, London, United Kingdom.
Clare JollyUniversity College London, London, United Kingdom.ORCID 0000-0002-4603-2281
Miguel E Quiñones-MateuDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Patrick S DakumInstitute for Human Virology, Abuja, Nigeria.
Nicaise Ndembi *Institute for Human Virology, Abuja, Nigeria.
Ravindra K Gupta *Department of Medicine, University of Cambridge, Cambridge, United Kingdom Rkg20@cam.ac.uk.ORCID 0000-0001-9751-1808
University College London · GBUniversity of Cambridge · GBUniversity of Maryland, Baltimore · USUniversity of Otago · NZ

Funding

Impact of Non - B HIV - 1 Subtype on second line Protease Inhibitor Regimens in Africa (INSPIRE)R01AI147331 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CHARURAT, MANHATTAN E, NDEMBI, NICAISE · 2020 to 2025
$2.9M
Department of HealthMedical Research Council G0801172Medical Research Council MR/S023380/1NIAID NIH HHS R01 AI147331PEPFARWellcome TrustWellcome Trust WT108082AIA
6 · The paper itself

Abstract

Protease inhibitors (PIs) are the second- and last-line therapy for the majority of HIV-infected patients worldwide. Only around 20% of individuals who fail PI regimens develop major resistance mutations in protease. We sought to explore the role of mutations in

Indexed as

Drug Resistance, ViralAmino Acid SubstitutionDose-Response Relationship, Druggag Gene Products, Human Immunodeficiency VirusGenome, ViralGenotypeHIV-1HIV AntigensHIV InfectionsHumansMicrobial Sensitivity TestsMutationPhenotypePhylogenyProtease InhibitorsSequence Deletiongag Gene Products, Human Immunodeficiency VirusHIV Antigensp17 protein, Human Immunodeficiency Virus Type 1Protease InhibitorsAfricaantiretroviralantiretroviral resistancedrugGagHIVhuman immunodeficiency virusproteaseprotease inhibitorsproteasesresistance

Identifiers

PMID33144375
PMCPMC7642677
OpenAlexW3097197480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.