Evidence map›Paper›PMID 33144311›Full record

ArticlemSystems2020

The Protein-Protein Interaction Network Reveals a Novel Role of the Signal Transduction Protein PII in the Control of c-di-GMP Homeostasis in Azospirillum brasilense.

Edileusa C M Gerhardt, Erick Parize, Fernanda Gravina, Flávia L D Pontes, Adrian R S Santos, Gillize A T Araújo, Ana C Goedert, Alysson H Urbanski, Maria B R Steffens, Leda S Chubatsu and 7 more

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. International journal of molecular sciences · 2021
    Article
  8. Article
  9. CdgC, a Cyclic-di-GMP Diguanylate Cyclase ofFrontiers in plant science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Edileusa C M GerhardtDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil.
Erick ParizeDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil.ORCID https://orcid.org/0000-0002-3878-0810
Fernanda GravinaDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil.
Flávia L D PontesDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil.
Adrian R S SantosDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil.
Gillize A T AraújoDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil.
Ana C GoedertDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil.
Alysson H UrbanskiDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil.
Maria B R SteffensDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil.
Leda S ChubatsuDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil.
Fabio O PedrosaDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil.
Emanuel M SouzaDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil.
Karl ForchhammerInterfakultäres Institut für Mikrobiologie und Infektionsmedizin der Eberhard-Karls Universität Tübingen, Tübingen, Germany.
Elena GanusovaDepartment of Biochemistry, Cellular & Molecular Biology, The University of Tennessee, Knoxville, Tennessee, USA.
Gladys AlexandreDepartment of Biochemistry, Cellular & Molecular Biology, The University of Tennessee, Knoxville, Tennessee, USA.ORCID https://orcid.org/0000-0002-9238-4640
Gustavo A de SouzaDepartamento de Bioquímica, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
Luciano F HuergoDepartamento de Bioquímica e Biologia Molecular, UFPR Curitiba, Curitiba, PR, Brazil luciano.huergo@gmail.com.ORCID https://orcid.org/0000-0002-7587-9510
Universidade Federal do Paraná · BRUniversity of Tennessee at Knoxville · USUniversidade Federal do Rio Grande do Norte · BRUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The PII family comprises a group of widely distributed signal transduction proteins ubiquitous in prokaryotes and in the chloroplasts of plants. PII proteins sense the levels of key metabolites ATP, ADP, and 2-oxoglutarate, which affect the PII protein structure and thereby the ability of PII to interact with a range of target proteins. Here, we performed multiple ligand fishing assays with the PII protein orthologue GlnZ from the plant growth-promoting nitrogen-fixing bacterium

Indexed as

c-di-GMPcell motilitymetabolic regulationmetabolomemotilityPII proteinprotein interactionprotein interactions

Identifiers

PMID33144311
PMCPMC7646526
OpenAlexW3096095807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.