ArticlemSystems2020
Correlations between α-Linolenic Acid-Improved Multitissue Homeostasis and Gut Microbiota in Mice Fed a High-Fat Diet.
Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 125 citations in OpenAlex.
- Gut microbiome responses to dietary intervention with hypocholesterolemic vegetable oils.NPJ biofilms and microbiomes · 2022Trial
- Dietary Supplementation of Protease and/or Amylase Improves Growth Performance, Digestive Function, and Intestinal Health of Weaned Piglets.Animals : an open access journal from MDPI · 2026Article
- Review
- Gut microbiota restructured by social isolation: Evidence for sex-specific response patterns.Brain, behavior, & immunity - health · 2026Article
- Periodontitis aggravates high-fat diet-induced MASLD via gut microbiota dysbiosis and metabolic dysfunction in mice.Scientific reports · 2026Article
- Composition and diversity of gastrointestinal tract fungi in finishing bulls fed different medium-chain fatty acid triglycerides.BMC microbiology · 2026Article
- LRRK2NPJ Parkinson's disease · 2026Article
- Maternal gestational diabetes mellitus leads to adverse growth patterns and disease risk in offspring in vivo: evidence from cross-generational effects on gut microbiota.BMC microbiology · 2026Article
- High-fat diet-induced osteoporosis in mice under hypoxic conditions.BMC musculoskeletal disorders · 2025Article
- Physiological and Metabolic Responses of Mongolian Horses to a 20 km Endurance Exercise and Screening for New Oxidative-Imbalance Biomarkers.Animals : an open access journal from MDPI · 2025Article
- Fermented Kamut Wheat Diet Prevents DSS-Induced Colitis via Modulating Gut Microbiota in Mice.International journal of molecular sciences · 2025Article
- Article
- Complex Probiotics Suppress Inflammation by Regulating Intestinal Metabolites in Kittens.Animals : an open access journal from MDPI · 2025Article
- Article
- Alpha-linolenic acid reshapes the gastrointestinal ecology to enhance immune function in dairy cows: insights from microbiome and metabolome profiling.Frontiers in microbiology · 2025Article
- Article
- The effects of functional biscuits on intestinal mucosal microbiota composition, brain function, and antioxidant activity.Bioscience of microbiota, food and health · 2025Article
- Article
- Impact of Dietary Fatty Acid Composition on the Intestinal Microbiota and Fecal Metabolism of Rats Fed a High-Fructose/High-Fat Diet.Nutrients · 2024Article
- Can longer lifespan be associated with gut microbiota involvement in lipid metabolism?FEMS microbiology ecology · 2024Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown that α-linolenic acid (ALA) has a significant regulatory effect on related disorders induced by high-fat diets (HFDs), but little is known regarding the correlation between the gut microbiota and disease-related multitissue homeostasis. We systematically investigated the effects of ALA on the body composition, glucose homeostasis, hyperlipidemia, metabolic endotoxemia and systemic inflammation, white adipose tissue (WAT) homeostasis, liver homeostasis, intestinal homeostasis, and gut microbiota of mice fed an HFD (HFD mice). We found that ALA improved HFD-induced multitissue metabolic disorders and gut microbiota disorders to various degrees. Importantly, we established a complex but clear network between the gut microbiota and host parameters. Several specific differential bacteria were significantly associated with improved host parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.