Evidence map›Paper›PMID 33144178›Full record

ArticleBehavioural brain research2021

Foot shock facilitates reward seeking in an experience-dependent manner.

J A Strickland, A D Dileo, M Moaddab, M H Ray, R A Walker, K M Wright, M A McDannald

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J A StricklandBoston College, Department of Psychology & Neuroscience, Chestnut Hill, MA, USA. Electronic address: jasmin.strickland@bc.edu.
A D DileoTufts University School of Medicine, School of Graduate Biomedical Sciences, Boston, MA, USA.
M MoaddabBoston College, Department of Psychology & Neuroscience, Chestnut Hill, MA, USA.
M H RayBoston College, Department of Psychology & Neuroscience, Chestnut Hill, MA, USA.
R A WalkerBoston College, Department of Psychology & Neuroscience, Chestnut Hill, MA, USA.
K M WrightBoston College, Department of Psychology & Neuroscience, Chestnut Hill, MA, USA.
M A McDannaldBoston College, Department of Psychology & Neuroscience, Chestnut Hill, MA, USA. Electronic address: michael.mcdannald@bc.edu.

Funding

Early life stress, neuron-type function and a raphe-amygdala circuit for threat estimationR01MH117791 · NIMH · BOSTON COLLEGE · PI MCDANNALD, MICHAEL A · 2018 to 2025
$4.0M
Retrorubral field control of fearR21MH113053 · NIMH · BOSTON COLLEGE · PI MCDANNALD, MICHAEL A · 2017 to 2018
$430k
NIMH NIH HHS R01 MH117791NIMH NIH HHS R21 MH113053
6 · The paper itself

Abstract

Animals organize reward seeking around aversive events. An abundance of research shows that foot shock, as well as a shock-associated cue, can elicit freezing and suppress reward seeking. Yet, there is evidence that experience can flip the effect of foot shock to facilitate reward seeking. Here we examined cue suppression, foot shock suppression and foot shock facilitation of reward seeking in a single behavioural setting. Male Long Evans rats received fear discrimination consisting of danger, uncertainty, and safety cues. Discrimination took place over a baseline of rewarded nose poking. With limited experience (1-2 sessions), all cues and foot shock suppressed reward seeking. With continued experience (10-16 sessions), suppression became specific to shock-associated cues, foot shock briefly suppressed, then facilitated reward seeking. Our results provide a means of assessing positive properties of foot shock, and may provide insight into maladaptive behaviour around aversive events.

Indexed as

RewardAnimalsBehavior, AnimalCuesDiscrimination LearningElectric StimulationFearMaleRatsRats, Long-EvansTransfer, PsychologyFear discriminationFoot shockOpponent processRewardTransfer

Identifiers

PMID33144178
PMCPMC7855116

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.