ArticlePsychological medicine2022
Dynamic interplay between life events and course of psychotic disorders: 10-year longitudinal study following first admission.
Article in Psychological medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Stressful life events and their association with symptom severity and functioning in first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- The Regulation of Frontal Cortex Cholesterol Metabolism Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of Stress-Induced Depression.International journal of molecular sciences · 2024Article
- Revisiting delusion subtypes in schizophrenia based on their underlying structures.Journal of psychiatric research · 2024Article
- Effects of independent versus dependent stressful life events on major symptom domains of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Spurious Autobiographical Memory of Psychosis: A Mechanistic Hypothesis for the Resolution, Persistence, and Recurrence of Positive Symptoms in Psychotic Disorders.Brain sciences · 2023Article
- Epigenetic clocks in relapse after a first episode of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLife events (LEs) are a risk factor for first onset and relapse of psychotic disorders. However, the impact of LEs on specific symptoms - namely reality distortion, disorganization, negative symptoms, depression, and mania - remains unclear. Moreover, the differential effects of negative
methodsThe present study utilizes an epidemiologic cohort of patients (
resultsWe examined symptom change within-person and found that negative events in the previous 6 months predicted an increase in reality distortion (
conclusionsThese findings confirm that LEs have an effect on symptoms, and thus contribute to the burden of psychotic disorders. That LEs increase positive symptoms and decrease negative symptoms suggest at least two different mechanisms underlying the relationship between LEs and symptoms. Our findings underscore the need for increased symptom monitoring following negative LEs, as symptoms may worsen during that time.
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Registered trials
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