ArticleBMC medicine2020
Impact of Covid-19 in pregnancy on mother's psychological status and infant's neurobehavioral development: a longitudinal cohort study in China.
Article in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 7 of them syntheses that pooled it.
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Who cites it
54 citing papers in PubMed, 7 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Impact of SARS-Cov-2 exposure during pregnancy on child neurodevelopment: systematic review and meta-analysis.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025Pooled it
- Effects of intrauterine exposure to SARS-CoV-2 on infants' development: a rapid review and meta-analysis.European journal of pediatrics · 2023Pooled it
- Neonatal outcomes and indirect consequences following maternal SARS-CoV-2 infection in pregnancy: a systematic review.BMJ open · 2023Pooled it
- The prevalence of mental ill-health in women during pregnancy and after childbirth during the Covid-19 pandemic: a systematic review and Meta-analysis.BMC pregnancy and childbirth · 2023Pooled it
- Psychiatric and neuropsychiatric sequelae of COVID-19 - A systematic review.Brain, behavior, and immunity · 2021Pooled it
- One Year Into the Pandemic: A Systematic Review of Perinatal Mental Health Outcomes During COVID-19.Frontiers in psychiatry · 2021Pooled it
- The Impact of Covid-19 on Women's Mental Health and Wellbeing During Pregnancy and the Perinatal Period: A Mixed-Methods Systematic Review.Inquiry : a journal of medical care organization, provision and financingPooled it
- Association between maternal SARS-CoV-2 infection & clinical outcomes in infants: A multicentric retrospective cohort study in India.The Indian journal of medical research · 2025Article
- Maternal COVID-19 infection associated with offspring neurodevelopmental disorders.Molecular psychiatry · 2025Article
- The Effect of COVID-19 on Neonatal Outcomes in a Community Hospital.Journal of clinical medicine · 2025Article
- The relationship between anxiety, depression, and COVID-19 diagnosis in term pregnancy: a hospital-based Romanian study.Medicine and pharmacy reports · 2025Article
- Predictors influencing neurodevelopment during the infancy of term infants.Frontiers in pediatrics · 2025Article
- Effect of pandemic-induced PTSD in pregnant women on infant physical growth: a prospective cohort study.BMC pediatrics · 2024Article
- Role of home nurturing environment on early childhood neurodevelopment: a community-based survey in Shanghai, China.BMC pediatrics · 2024Article
- Prenatal mental health and emotional experiences during the pandemic: associations with infant neurodevelopment screening results.Pediatric research · 2024Article
- Psychological interventions to pregnancy-related complications in patients with post-traumatic stress disorder: a scoping review.BMC psychiatry · 2024Article
- Navigation of Knowledge: the Impact of COVID-19 on Pregnancy-a Bibliometric Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Maternal immune activation and role of placenta in the prenatal programming of neurodevelopmental disorders.Neuronal signaling · 2023Review
- Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma.Communications medicine · 2023Article
- Sex-Specific Neurodevelopmental Outcomes Among Offspring of Mothers With SARS-CoV-2 Infection During Pregnancy.JAMA network open · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEvidence concerning the long-term impact of Covid-19 in pregnancy on mother's psychological disorder and infant's developmental delay is unknown.
methodsThis study is a longitudinal single-arm cohort study conducted in China between May 1 and July 31, 2020. Seventy-two pregnant patients with Covid-19 participated in follow-up surveys until 3 months after giving birth (57 cases) or having abortion (15 cases). We collected data from medical records regarding Covid-19, delivery or abortion, testing results of maternal and neonatal specimens, and questionnaires of quarantine, mother-baby separation, feeding, and measuring of mothers' mental disorders and infants' neurobehavioral disorders.
resultsAll cases infected in the first trimester and 1/3 of cases infected in the second trimester had an abortion to terminate the pregnancy. 22.2% of pregnant patients were suffering from post-traumatic stress disorder or depression at 3 months after delivery or induced abortion. Among 57 live births, only one neonate was positive of nucleic acid testing for throat swab, but negative in repeated tests subsequently. The median duration of mother-baby separation was 35 days (interquartile range 16 to 52 days). After the termination of maternal quarantine, 49.1% of mothers chose to prolong the mother-baby separation (median 8 days; IQR 5 to 23 days). The breastfeeding rate was 8.8% at 1 week after birth, 19.3% at the age of 1 month, and 36.8% at the age of 3 months, respectively. The proportion of "monitoring" and "risk" in the social-emotional developmental domain at the age of 3 months was 22.7% and 63.6%, respectively. After the adjustment of preterm, neonatal sex, admitted to NICU, and the mother's Covid-19 condition, the negative associations were significantly identified (p < 0.05) between mother-baby separation days and three developmental domains: communication, gross motor, and personal-social.
conclusionsThere is no definite evidence on vertical transmission of SARS-CoV-2. In addition to control infection risk, researchers and healthcare providers should pay more attention to maternal mental health and infant's feeding, closeness with parents, and early development.
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