ArticleBMC genomics2020
Sex differences in early transcriptomic responses to oxidative stress in the copepod Tigriopus californicus.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Heat exposure improves acute copper tolerance in the intertidal copepod Tigriopus californicus.Environmental science and pollution research international · 2026Article
- The role of mitochondria in sex- and age-specific gene expression in a species without sex chromosomes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The role of mitochondria in sex- and age-specific gene expression in a species without sex chromosomes.bioRxiv : the preprint server for biology · 2023Article
- Article
- Mitochondrial effects on fertility and longevity inProceedings. Biological sciences · 2022Article
- Food deprivation exposes sex-specific trade-offs between stress tolerance and life span in the copepodEcology and evolution · 2022Article
- Mitonuclear interactions alter sex-specific longevity in a species without sex chromosomes.Proceedings. Biological sciences · 2021Article
- Susceptibility of the Non-Targeted CrustaceanGenes · 2021Article
- Evidence for hybrid breakdown in production of red carotenoids in the marine invertebrate Tigriopus californicus.PloS one · 2021Article
- First De Novo Transcriptome of the CopepodBiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPatterns of gene expression can be dramatically different between males and females of the same species, in part due to genes on sex chromosomes. Here we test for sex differences in early transcriptomic response to oxidative stress in a species which lacks heteromorphic sex chromosomes, the copepod Tigriopus californicus.
resultsMale and female individuals were separately exposed to control conditions and pro-oxidant conditions (hydrogen peroxide and paraquat) for periods of 3 hours and 6 hours. Variance partitioning showed the greatest expression variance among individuals, highlighting the important information that can be obscured by the common practice of pooling individuals. Gene expression variance between sexes was greater than that among treatments, showing the profound effect of sex even when males and females share the same genome. Males exhibited a larger response to both pro-oxidants, differentially expressing more than four times as many genes, including up-regulation of more antioxidant genes, heat shock proteins and protease genes. While females differentially expressed fewer genes, the magnitudes of fold change were generally greater, indicating a more targeted response. Although females shared a smaller fraction of differentially expressed genes between stressors and time points, expression patterns of antioxidant and protease genes were more similar between stressors and more GO terms were shared between time points.
conclusionsEarly transcriptomic responses to the pro-oxidants H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.