Evidence map›Paper›PMID 33143532›Full record

ArticleJournal of psychopharmacology (Oxford, England)2020

Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression.

Liliana P Capitão, Robert Chapman, Nicola Filippini, Lucy Wright, Susannah E Murphy, Anthony James, Phil J Cowen, Catherine J Harmer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Liliana P CapitãoDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0003-3117-5156
Robert ChapmanDepartment of Psychiatry, University of Oxford, Oxford, UK.
Nicola FilippiniDepartment of Psychiatry, University of Oxford, Oxford, UK.
Lucy WrightDepartment of Psychiatry, University of Oxford, Oxford, UK.
Susannah E MurphyDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0001-8995-2099
Anthony JamesDepartment of Psychiatry, University of Oxford, Oxford, UK.
Phil J CowenDepartment of Psychiatry, University of Oxford, Oxford, UK.
Catherine J HarmerDepartment of Psychiatry, University of Oxford, Oxford, UK.
Oxford Health NHS Foundation Trust · GBUniversity of Oxford · GB

Funding

Medical Research Council 85077
6 · The paper itself

Abstract

Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the effects of a single dose of fluoxetine vs. placebo in adolescents with major depressive disorder. In contrast with previous studies in adults that have demonstrated an acute effect of antidepressants on activity within the default mode network, a single dose of fluoxetine did not alter activity in this network in adolescent depression. There were unexpected group activity differences in the motor network, which should be clarified in future research.

Indexed as

Cerebral CortexConnectomeDefault Mode NetworkMajor Depressive DisorderAdolescentFemaleFluoxetineHumansMagnetic Resonance ImagingMaleSelective Serotonin Reuptake InhibitorsFluoxetineSelective Serotonin Reuptake Inhibitorsadolescent depressionFluoxetineresting-state functional connectivity

Identifiers

PMID33143532
PMCPMC7708665
OpenAlexW3096363774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.