ArticleAutophagy2021
Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3.
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In one paragraph
Article in Autophagy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 3 pooled it
8.9field-weighted citation impact, top 1% of its field
What it found
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Who cites it
97 citing papers in PubMed, 3 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Genetically modified stem cells for osteoporosis: a systematic review and meta-analysis of preclinical studies.BMC musculoskeletal disorders · 2025Pooled it
- Rejuvenation of Bone Marrow Mesenchymal Stem Cells: Mechanisms and Their Application in Senile Osteoporosis Treatment.Biomolecules · 2025Pooled it
- Consequences of Aging on Bone.Aging and disease · 2023Pooled it
- Stem cell senescence as a regenerative bottleneck in age-related skeletal degeneration: Mechanistic crosstalk and translational strategies.Regenerative therapy · 2026Review
- Biomimetic nanoparticles camouflaged with M2 macrophage membrane for osteoporosis therapy: A triple-action strategy that upregulates anti-inflammation and osteogenic responses while suppressing MMP-9.Materials today. Bio · 2026Article
- Dysregulation of the MACF1-Rab14/KIF16B-FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid-Induced Osteoporosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Marrow fatty acids in osteoporosis: metabolic insights, emerging therapeutic targets.Journal of bone and mineral metabolism · 2026Review
- The Rising Burden of Osteosarcopenia in Older Adults: A Narrative Review of Pathophysiology, Diagnostic Challenges, and Therapeutic Perspectives.Health science reports · 2026Article
- BMSC-targeting aptamer conjugation enhances bone delivery of a rice bran peptide to mitigate osteoporosis via eIF3L.Materials today. Bio · 2026Article
- Meis1-driven suppression of MIF/CD74 signaling promotes M2 macrophage polarization and protects against inflammatory damage in experimental acute lung injury.Cell biology and toxicology · 2026Article
- TSPO governs bone-lipid homeostasis by redirecting BMSC differentiation via the PI3K/AKT/β-catenin pathway.Stem cell research & therapy · 2026Article
- Vitamin D and Metabolic Dysfunction-Associated Steatotic Liver Disease: Molecular Mechanisms and Clinical Implications-A Narrative Review.International journal of molecular sciences · 2026Review
- Marine-Derived Quinolinone CHNQD-00603 Triggers Autophagy via Suppressing the AKT/ERK/mTOR Pathway to Reverse Senescence and Restore Osteogenic Potential in Bone Marrow Mesenchymal Stem Cells.Current protein & peptide science · 2026Article
- ATG5-overexpressing MSCs improve ligament healing with an associated shift toward M2 macrophage polarization in aged rats.Open medicine (Warsaw, Poland) · 2026Article
- Cellular senescence in musculoskeletal diseases: biological mechanisms and clinical implications.Theranostics · 2026Review
- STAT1 promotes ferroptosis and inflammation in mouse hepatic ischemia-reperfusion injury.Communications biology · 2025Article
- 5'-Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation-Mediated PAK2 Upregulation to Promote Cadmium-Induced Breast Cancer Progression by Impairing Autophagic Flux.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Pak4-mediated crosstalk between necroptotic macrophages and tendon stem/progenitor cells contributes to traumatic heterotopic ossification formation.Bone research · 2025Article
- Exercise-driven cellular autophagy: A bridge to systematic wellness.Journal of advanced research · 2025Review
- Identification and validation of the cellular senescence-associated molecular pattern and diagnostic markers for osteoporosis.BMC medical genomics · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 2 institutions in 1 country.
Zheng-Zhao LiuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chun-Gu HongMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wen-Bao HuShenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.ORCID 0000-0003-4250-7152
Meng-Lu ChenMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ran DuanMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hong-Ming LiDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Tao YueDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jia CaoMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhen-Xing WangMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chun-Yuan ChenDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiong-Ke HuMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ben WuMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hao-Ming LiuMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yi-Juan TanMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jiang-Hua LiuDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhong-Wei LuoDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yan ZhangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Shan-Shan RaoMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ming-Jie LuoMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hao YinDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yi-Yi WangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Kun XiaDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lang XuMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Si-Yuan TangXiangya Nursing School, Central South University, Changsha, Hunan, China.
Rong-Gui HuState Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network; Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Shanghai 200031, China.
Hui XieDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Central South University · CNChinese Academy of Sciences · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Senile osteoporosis (OP) is often concomitant with decreased autophagic activity. OPTN (optineurin), a macroautophagy/autophagy (hereinafter referred to as autophagy) receptor, is found to play a pivotal role in selective autophagy, coupling autophagy with bone metabolism. However, its role in osteogenesis is still mysterious. Herein, we identified
Indexed as
AgingAutophagyCell Cycle ProteinsFatty Acid Binding Protein 3Membrane Transport ProteinsMesenchymal Stem CellsAdipogenesisAnimalsCell DifferentiationMiceOsteogenesisOsteoporosisX-Ray MicrotomographyCell Cycle ProteinsFabp3 protein, mouseFatty Acid Binding Protein 3Membrane Transport ProteinsOptn protein, mouseAdipogenesisautophagybone metabolismfabp3mesenchymal stem celloptineurinosteogenesisosteoporosissenescence
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.