Evidence map›Paper›PMID 33143260›Full record

ReviewMolecules (Basel, Switzerland)2020

Transdermal Delivery Systems of Natural Products Applied to Skin Therapy and Care.

Ying-Chen Cheng, Tzong Shiun Li, Hong Lin Su, Po Chun Lee, Hui-Min David Wang

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Mixture Containing 5% Polysaccharide Extract ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Preparation of theInternational journal of nanomedicine · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ying-Chen ChengGraduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung City 402, Taiwan.
Tzong Shiun LiDepartment of Plastic Surgery, Show Chwan Memorial Hospital, Changhua 500, Taiwan.
Hong Lin SuDepartment of Life Sciences, National Chung Hsing University, Taichung City 402, Taiwan.
Po Chun LeeCardiovascular Clinic, Kaohsiung Armed Forces General Hospital, Kaohsiung City 802, Taiwan.ORCID 0000-0002-3985-7517
Hui-Min David WangGraduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung City 402, Taiwan.ORCID 0000-0002-5162-9752

Funding

Ministry of Science and Technology OST 108-2221-E-005-044 and MOST 109-2221-E-005-012
6 · The paper itself

Abstract

Natural products are favored because of their non-toxicity, low irritants, and market reacceptance. We collected examples, according to ancient wisdom, of natural products to be applied in transdermal delivery. A transdermal delivery system, including different types of agents, such as ointments, patches, and gels, has long been used for skin concerns. In recent years, many novel transdermal applications, such as nanoemulsions, liposomes, lipid nanoparticles, and microneedles, have been reported. Nanosized drug delivery systems are widely applied in natural product deliveries. Nanosized materials notably enhance bioavailability and solubility, and are reported to improve the transdermal permeation of many substances compared with conventional topical formulations. Natural products have been made into nanosized biomaterials in order to enhance the penetration effect. Before introducing the novel transdermal applications of natural products, we present traditional methods within this article. The descriptions of novel transdermal applications are classified into three parts: liposomes, emulsions, and lipid nanoparticles. Each section describes cases that are related to promising natural product transdermal use. Finally, we summarize the outcomes of various studies on novel transdermal agents applied to skin treatments.

Indexed as

Biological ProductsDrug Delivery SystemsNanoparticlesSkin AbsorptionAdministration, CutaneousChemistry, PharmaceuticalHumansLiposomesBiological ProductsLiposomesemulsionlipid nanoparticleliposomenatural productsskintransdermal delivery

Identifiers

PMID33143260
PMCPMC7662758

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.