Evidence map›Paper›PMID 33143240›Full record

ReviewInternational journal of molecular sciences2020

Hypoxia Pathway Proteins are Master Regulators of Erythropoiesis.

Deepika Watts, Diana Gaete, Diego Rodriguez, David Hoogewijs, Martina Rauner, Sundary Sormendi, Ben Wielockx

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Randomized phase II dose comparison LITESPARK-013 study of belzutifan in patients with advanced clear cell renal cell carcinoma.Annals of oncology : official journal of the European Society for Medical Oncology · 2024
    Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. ACS pharmacology & translational science · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. HIF1α controls steroidogenesis under acute hypoxic stress.Cell communication and signaling : CCS · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Deepika WattsInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.
Diana GaeteInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0003-4739-2884
Diego RodriguezInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.
David HoogewijsSection of Medicine, Department of Endocrinology, Metabolism and Cardiovascular System, University of Fribourg, 1700 Fribourg, Switzerland.
Martina RaunerDepartment of Medicine III and Center for Healthy Aging, Technische Universität Dresden, 01307 Dresden, Germany.
Sundary SormendiInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.
Ben WielockxInstitute of Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0002-4923-2596
Technische Universität Dresden · DEUniversity of Fribourg · CH

Funding

Deutsche Forschungsgemeinschaft CRC/Transregio 205/1, Project No. 314061271 - TRR205, "The Adrenal: Central Relay in Health and Disease"Deutsche Forschungsgemeinschaft WI3291/5-1 and 12-1Deutsche Forschungsgemeinschaft µBONE 2084
6 · The paper itself

Abstract

Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO-producing cells. The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO

Indexed as

ErythropoiesisAnemiaAnimalsBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1HumansHypoxiaHypoxia-Inducible Factor 1Basic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1Hypoxia-Inducible Factor 1CKDEPOerythropoiesisHIFhypoxia

Identifiers

PMID33143240
PMCPMC7662373
OpenAlexW3092383016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.