Evidence map›Paper›PMID 33143109›Full record

ArticleMolecules (Basel, Switzerland)2020

Condition-Dependent Coordination and Peroxidase Activity of Hemin-Aβ Complexes.

Chiara Bacchella, James T Brewster, Steffen Bähring, Simone Dell'Acqua, Harrison D Root, Gregory D Thiabaud, James F Reuther, Enrico Monzani, Jonathan L Sessler, Luigi Casella

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Chiara BacchellaDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0003-3256-8699
James T BrewsterDepartment of Chemistry, The University of Texas at Austin, 105 East 24th, Street-Stop A5300, Austin, TX 78712-1224, USA.ORCID 0000-0002-4579-8074
Steffen BähringDepartment of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.
Simone Dell'AcquaDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-1231-4045
Harrison D RootDepartment of Chemistry, The University of Texas at Austin, 105 East 24th, Street-Stop A5300, Austin, TX 78712-1224, USA.
Gregory D ThiabaudDepartment of Chemistry, The University of Texas at Austin, 105 East 24th, Street-Stop A5300, Austin, TX 78712-1224, USA.
James F ReutherDepartment of Chemistry, The University of Texas at Austin, 105 East 24th, Street-Stop A5300, Austin, TX 78712-1224, USA.ORCID 0000-0001-5611-0290
Enrico MonzaniDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-8791-6446
Jonathan L SesslerDepartment of Chemistry, The University of Texas at Austin, 105 East 24th, Street-Stop A5300, Austin, TX 78712-1224, USA.
Luigi CasellaDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-7671-0506
The University of Texas at Austin · USUniversity of Pavia · ITUniversity of Massachusetts Lowell · USUniversity of Southern Denmark · DK

Funding

Danish Council for Independent Research 5054-00052Italian Ministry of Education 2015T778JWNIH HHS CA68682Welch Foundation F-0018
6 · The paper itself

Abstract

The peroxidase activity of hemin-peptide complexes remains a potential factor in oxidative damage relevant to neurodegeneration. Here, we present the effect of temperature, ionic strength, and pH relevant to pathophysiological conditions on the dynamic equilibrium between high-spin and low-spin hemin-Aβ

Indexed as

Amyloid beta-PeptidesBenzothiazolesDopamineHeminHumansOxidation-ReductionPeptide FragmentsPeroxidasesSulfonic Acids2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acidAmyloid beta-Peptidesamyloid beta-protein (1-40)BenzothiazolesDopamineHeminPeptide FragmentsPeroxidasesSulfonic AcidsAlzheimer’s diseasecentral nervous systemheminneurodegenerationperoxidase

Identifiers

PMID33143109
PMCPMC7662341
OpenAlexW3096332065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.