Evidence map›Paper›PMID 33142954›Full record

ArticleInternational journal of molecular sciences2020

Structural Insight on Functional Regulation of Human MINERVA Protein.

Hyunggu Hahn, Dong-Eun Lee, Dong Man Jang, Jiyoun Kim, Yeon Lee, Heesun Cheong, Byung Woo Han, Hyoun Sook Kim

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hyunggu HahnResearch Institute, National Cancer Center, Goyang, Gyeonggi 10408, Korea.
Dong-Eun LeeResearch Institute, National Cancer Center, Goyang, Gyeonggi 10408, Korea.
Dong Man JangResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea.ORCID 0000-0003-0701-0503
Jiyoun KimResearch Institute, National Cancer Center, Goyang, Gyeonggi 10408, Korea.
Yeon LeeResearch Institute, National Cancer Center, Goyang, Gyeonggi 10408, Korea.
Heesun CheongResearch Institute, National Cancer Center, Goyang, Gyeonggi 10408, Korea.ORCID 0000-0003-1946-107X
Byung Woo HanResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea.ORCID 0000-0001-7571-3791
Hyoun Sook KimResearch Institute, National Cancer Center, Goyang, Gyeonggi 10408, Korea.ORCID 0000-0003-1095-6463
National Cancer Center · KRSeoul National University · KR

Funding

National Cancer Center Grant of Korea NCC-1910023National Cancer Center Grant of Korea NCC-1910032National Research Foundation of Korea NRF-2017R1C1B2012225National Research Foundation of Korea NRF-2020R1A2B5B01002011National Research Foundation of Korea NRF-2020R1C1C1009512
6 · The paper itself

Abstract

MINERVA (melanoma invasion by ERK), also known as FAM129B, is a member of the FAM129 protein family, which is only present in vertebrates. MINERVA is involved in key signaling pathways regulating cell survival, proliferation and apoptosis and found upregulated in many types of cancer promoting invasion. However, the exact function of the protein remains elusive. X-ray crystallographic methods were implemented to determine the crystal structure of MINERVA

Indexed as

Cell MembraneCrystallography, X-RayHumansMelanomaModels, MolecularPhosphoproteinsProtein BindingProtein Structure, TertiarySequence Homology, Amino AcidSignal TransductionNIBAN2 protein, humanPhosphoproteinscancer progressionFAM129Binvasionlipid bindingMINERVAnovel foldPH domain

Identifiers

PMID33142954
PMCPMC7663100
OpenAlexW3097007975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.