Evidence map›Paper›PMID 33142938›Full record

ReviewInternational journal of molecular sciences2020

Prevention of Diabetes and Cardiovascular Disease in Obesity.

Lucia La Sala, Antonio E Pontiroli

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05987410 (EffectiVenEss of a Rehabilitation Treatment With Nordic Walking in obEse or oveRweight Diabetic patiEnts With Cardiovascular Disease. The VENERE Study), which is not on this map. Cited by 95 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 5 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05987410 narecruitingnot on this mapstarted 2023, after this paper: background citation

EffectiVenEss of a Rehabilitation Treatment With Nordic Walking in obEse or oveRweight Diabetic patiEnts With Cardiovascular Disease. The VENERE Study

TypeinterventionalSponsorFondazione Don Carlo Gnocchi ETSRan2023 to 2026Enrolled105ConditionsCardiovascular Diseases, Diabete Type 2, Overweight and ObesityArmsNordic Walking (NW), Standard Rehabilitation (SR), Cardiological Counselling (CC)
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 5 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Pooled it
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  13. Improving glucose tolerance in obese rats: the role of Jinlida granules ( ) in gut microbiota modulation.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
    Article
  14. Recombinant Macrophage Migration Inhibitory Factor Derived fromInternational journal of molecular sciences · 2026
    Article
  15. Prediabetes: a new indication for GLP-1s?International journal of obesity (2005) · 2026
    Review
  16. Review
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  20. Histidine-Containing Dipeptides in Obesity and Cardiometabolic Health: A Systematic Scoping Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Article

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Lucia La SalaLaboratory of Cardiovascular and Dysmetabolic Disease, IRCCS MultiMedica, 20138 Milan, Italy.
Antonio E PontiroliDipartimento di Scienze della Salute, Università degli Studi di Milano, 20142 Milan, Italy.
MultiMedica · ITUniversity of Milan · IT

Funding

Fondazione Romeo ed Enrica Invernizzi RicercaMinistero della Salute Ricerca Corrente
6 · The paper itself

Abstract

Obesity is one of the major risk factors for the development of both impaired glucose tolerance (IGT, or prediabetes) and type 2 diabetes (T2D), and its prevalence worldwide drives toward an increased rate of cardiovascular morbidity and mortality. Given the estimations of the World Health Organization (WHO) and the recommendation of the Diabetes Prevention Program (DPP), where IGT and diabetes are considered as risk factors for the development of cardiovascular complications and obesity, the development of diabetes should be treated because of its potential reversibility. In this view, several interventions such as diet, lifestyle changes, and pharmacological treatment are effective, including bariatric metabolic surgery (BMS), which is the most incisive way to efficiently lower body weight. In this review, we sought to summarize some of the major aspects linked to diabetes prevention in overweight/obesity, focusing on the use of surgery; we also attempted to elucidate molecular pathways involved in a variety of obesity-induced processes able to favor the progression of chronic diseases, such as diabetes and its complications.

Indexed as

Bariatric SurgeryCardiovascular DiseasesDiabetes Mellitus, Type 2DietExerciseHumansLife StyleObesityRisk Factorsatherosclerosiscardiovascular complicationsCVDdiabetesinflammationmetabolic syndromemicroRNAobesitypreventionT2D

Identifiers

PMID33142938
PMCPMC7663329
OpenAlexW3096535522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.