ArticleBiomedicines2020
Breath Ammonia Is a Useful Biomarker Predicting Kidney Function in Chronic Kidney Disease Patients.
Article in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 101 citations in OpenAlex.
- Development of a Low-Cost Portable Exhaled Breath Ammonia Detector for Supplementary Five-Stage CKD Classification Using Embedded Threshold Logic.Sensors (Basel, Switzerland) · 2026Article
- Linkage of gut microbiota dysbiosis to chronic kidney disease in patients with graded proteinuria levels.Microbiology spectrum · 2026Article
- Electronic nose technology in bronchial asthma diagnosis and management.Multidisciplinary respiratory medicine · 2026Article
- Real-Time Breath Diagnostics: Linking Molecular Pathways, Measurement Technologies, and Clinical Translation.International journal of molecular sciences · 2026Review
- Breath ammonia test for chronic kidney disease screening: impact of fasting on diagnostic accuracy.Clinical kidney journal · 2026Article
- Using Electrostatic Mapping to Understand PANI-MWCNTs' NHSensors (Basel, Switzerland) · 2026Article
- Opportunities and Challenges in Gas Sensor Technologies for Accurate Detection of COVID-19.Biosensors · 2025Review
- Enhanced Lung Cancer Classification Accuracy via Hybrid Sensor Integration and Optimized Fuzzy Logic-Based Electronic Nose.Sensors (Basel, Switzerland) · 2025Article
- Segatella copri and gut microbial ammonia metabolism contribute to chronic kidney disease pathogenesis.Nature microbiology · 2025Article
- Sulfonated reduced graphene oxide-doped polypyrrole film prepared by in situ electropolymerization and coating in fabrication of ammonia gas sensor for exhaled breath analysis of patients with kidney failure.Mikrochimica acta · 2025Article
- Advancements in Breathomics: Special Focus on Electrochemical Sensing and AI for Chronic Disease Diagnosis and Monitoring.ACS omega · 2025Review
- Machine Learning Model Discriminate Ischemic Heart Disease Using Breathome Analysis.Biomedicines · 2024Article
- Non-Invasive Diagnostic Approaches for Kidney Disease: The Role of Electronic Nose Systems.Sensors (Basel, Switzerland) · 2024Review
- Ammonia Detection by Electronic Noses for a Safer Work Environment.Sensors (Basel, Switzerland) · 2024Review
- Volatilome is Inflammasome- and Lipidome-dependent in Ischemic Heart Disease.Current cardiology reviews · 2024Review
- Breathomics Detect the Cardiovascular Disease: Delusion or Dilution of the Metabolomic Signature.Current cardiology reviews · 2024Review
- An Investigation on the Acetone and Ethanol Vapor-Sensing Behavior of Sol-Gel Electrospun ZnO Nanofibers Using an Indigenous Setup.ACS omega · 2023Article
- Article
- Microwave Gas Sensors Based on Electrodeposited Polypyrrole-Nickel Phthalocyanine Hybrid Films.Sensors (Basel, Switzerland) · 2023Article
- Breath-by-breath measurement of exhaled ammonia by acetone-modifier positive photoionization ion mobility spectrometry via online dilution and purging sampling.Journal of pharmaceutical analysis · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Chronic kidney disease (CKD) is a public health problem and its prevalence has increased worldwide; patients are commonly unaware of the condition. The present study aimed to investigate whether exhaled breath ammonia via vertical-channel organic semiconductor (V-OSC) sensor measurement could be used for rapid CKD screening. We enrolled 121 CKD stage 1-5 patients, including 19 stage 1 patients, 26 stage 2 patients, 38 stage 3 patients, 21 stage 4 patients, and 17 stage 5 patients, from July 2019 to January 2020. Demographic and laboratory data were recorded. The exhaled ammonia was collected and rapidly measured by the V-OSC sensor to correlate with kidney function. Results showed no significant difference in age, sex, body weight, hemoglobin, albumin level, and comorbidities in different CKD stage patients. Correlation analysis demonstrated a good correlation between breath ammonia and blood urea nitrogen levels, serum creatinine levels, and estimated glomerular filtration rate (eGFR). Breath ammonia concentration was significantly elevated with increased CKD stage compared with the previous stage (CKD stage 1/2/3/4/5: 636 ± 94; 1020 ± 120; 1943 ± 326; 4421 ± 1042; 12781 ± 1807 ppb,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.