ReviewToxins2020
Sialorrhea in Parkinson's Disease.
Review in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Guidelines for Parkinson's disease management part II: consensus from the movement disorders scientific department of the Brazilian Academy of Neurology - non-motor symptoms.Arquivos de neuro-psiquiatria · 2025Guideline
- Effectiveness of the pharmacological treatments for sialorrhea in patients with Parkinson's disease: a systematic review and network meta-analysis.Clinical oral investigations · 2023Pooled it
- Nurse-led management of sialorrhea in Parkinson's disease: a pilot randomized controlled trial.Frontiers in medicine · 2026Trial
- Symptom prevalence and pharmacological management of late-stage Parkinson's disease (LSPD): a cross-sectional, multinational survey.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Patient Perceptions on a Wearable Sensor Technology for Swallowing: A Qualitative Study with Patients with Parkinson's Disease.Dysphagia · 2026Article
- A Multimodal In-Ear Audio and Physiological Dataset for Swallowing and Non-Verbal Event Classification.Sensors (Basel, Switzerland) · 2026Article
- Relationships Between Swallowing Function, Sialorrhea, and Cervical Proprioception in Parkinson's Disease.Journal of clinical practice and research · 2026Article
- Clinical and autonomic correlates of chronic Sialorrhea in Parkinson's disease: a questionnaire-based study with cluster analysis of autonomic and dysphagia burden.Clinical parkinsonism & related disorders · 2026Article
- Review
- The Effect of Dopaminergic Therapies in Parkinson's Disease on Non-Motor Symptoms.International journal of molecular sciences · 2025Review
- Neurogenic Dysphagia: Peripheral and Central Neuromodulation.Clinics and practice · 2025Review
- Article
- Pan-Gut Dysmotility in Parkinson Disease.Gastroenterology & hepatology · 2025Article
- Redefining Non-Motor Symptoms in Parkinson's Disease.Journal of personalized medicine · 2025Review
- Effects of focal low energy extracorporeal shock wave treatment on reduction of sialorrhea in Parkinson's disease.Frontiers in neurology · 2025Article
- Sex-dependent alterations of salivary microbiome in Parkinson's disease: associations with motor and non-motor clinical phenotypes.Frontiers in molecular biosciences · 2025Article
- Molecular characterization of the circadian clock in patients with Parkinson's disease-CLOCK4PD Study protocol.PloS one · 2024Article
- The effectiveness of ultrasound-guided injection of BTX-A in the management of sialorrhea in neurogenic dysphagia patients.Laryngoscope investigative otolaryngology · 2023Article
- Drooling disrupts the brain functional connectivity network in Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- Dysphagia in Parkinson Disease: Part II-Current Treatment Options and Insights from Animal Research.Current physical medicine and rehabilitation reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sialorrhea, or excessive saliva beyond the margin of the lip, is a common problem in many neurological diseases. Previously, sialorrhea has been underrecognized in Parkinson's disease (PD) patients. Despite this, many patients rank sialorrhea as one of the most debilitating complaints of Parkinson's disease. Previous treatment for sialorrhea has been suboptimal and has been plagued by significant side effects that are bothersome and can be dangerous in patients with a concurrent neurodegenerative disease. This review sought to review the anatomy, function, and etiology of sialorrhea in PD. It then sought to examine the evidence for the different treatments of sialorrhea in PD, and further examined newer evidence for safety and efficacy in minimally invasive treatment such as botulinum toxin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.