Evidence map›Paper›PMID 33142804›Full record

ArticleCells2020

Dysbindin deficiency Alters Cardiac BLOC-1 Complex and Myozap Levels in Mice.

Ankush Borlepawar, Nesrin Schmiedel, Matthias Eden, Lynn Christen, Alexandra Rosskopf, Derk Frank, Renate Lüllmann-Rauch, Norbert Frey, Ashraf Yusuf Rangrez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ankush BorlepawarDepartment of Internal Medicine III (Cardiology, Angiology, Intensive Care), University Medical Center Kiel, 24105 Kiel, Germany.
Nesrin SchmiedelDepartment of Internal Medicine III (Cardiology, Angiology, Intensive Care), University Medical Center Kiel, 24105 Kiel, Germany.
Matthias EdenDepartment of Internal Medicine III (Cardiology, Angiology, Intensive Care), University Medical Center Kiel, 24105 Kiel, Germany.
Lynn ChristenDepartment of Internal Medicine III (Cardiology, Angiology, Intensive Care), University Medical Center Kiel, 24105 Kiel, Germany.
Alexandra RosskopfDepartment of Internal Medicine III (Cardiology, Angiology, Intensive Care), University Medical Center Kiel, 24105 Kiel, Germany.
Derk FrankDepartment of Internal Medicine III (Cardiology, Angiology, Intensive Care), University Medical Center Kiel, 24105 Kiel, Germany.
Renate Lüllmann-RauchInstitute of Anatomy, Christian-Albrechts-University Kiel, 24118 Kiel, Germany.
Norbert FreyDepartment of Internal Medicine III (Cardiology, Angiology, Intensive Care), University Medical Center Kiel, 24105 Kiel, Germany.
Ashraf Yusuf RangrezDepartment of Internal Medicine III (Cardiology, Angiology, Intensive Care), University Medical Center Kiel, 24105 Kiel, Germany.ORCID 0000-0003-2630-9754
German Centre for Cardiovascular Research · DEChristian-Albrechts-Universität zu Kiel · DEClinical Research Center Kiel · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysbindin, a schizophrenia susceptibility marker and an essential constituent of BLOC-1 (biogenesis of lysosome-related organelles complex-1), has recently been associated with cardiomyocyte hypertrophy through the activation of Myozap-RhoA-mediated SRF signaling. We employed sandy mice (

Indexed as

AnimalsCardiomegalyCytosolDysbindinGene Expression RegulationHypertrophyIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutMuscle ProteinsMyocytes, CardiacOrganelle BiogenesisProtein BindingrhoA GTP-Binding ProteinBloc1s6 protein, mouseDtnbp1 protein, mouseDysbindinIntracellular Signaling Peptides and ProteinsMuscle Proteinsmuted protein, mouseMyozap protein, mouserhoA GTP-Binding ProteinSerum Response FactorVesicular Transport Proteinscardiac hypertrophyDysbindinMutedMyozapPallidin

Identifiers

PMID33142804
PMCPMC7692170
OpenAlexW3097542809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.