Evidence map›Paper›PMID 33142781›Full record

ArticleBiosensors2020

Development of Surface-Enhanced Raman Scattering (SERS)-Based Surface-Corrugated Nanopillars for Biomolecular Detection of Colorectal Cancer.

Kuan-Hung Chen, Meng-Ju Pan, Zoljargal Jargalsaikhan, Tseren-Onolt Ishdorj, Fan-Gang Tseng

Abstract read
In one paragraph

Article in Biosensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kuan-Hung ChenInstitute of NanoEngineering and MicroSystems, National Tsing Hua University, HsinChu 30013, Taiwan.
Meng-Ju PanEngineering and System Science Dept., National Tsing Hua University, HsinChu 30013, Taiwan.
Zoljargal JargalsaikhanSchool of Information and Communication Technology, Mongolian University of Science and Technology, Ulaanbaatar 13341-0048, Mongolia.
Tseren-Onolt IshdorjSchool of Information and Communication Technology, Mongolian University of Science and Technology, Ulaanbaatar 13341-0048, Mongolia.ORCID 0000-0002-0425-3879
Fan-Gang TsengInstitute of NanoEngineering and MicroSystems, National Tsing Hua University, HsinChu 30013, Taiwan.ORCID 0000-0001-7654-6905

Funding

Ministry of Education, Taiwan MOE 107QR001I5Ministry of Science and Technology (MOST), Taiwan 106-2923-E-007-004-MY3, 107-2221-E-007-012-MY3, 107-2622-E-007-006-CC2, 108-3017-F-007-0032Veterans General Hospitals and University System of Taiwan Joint Research Program VGHUST107-G6-1-1, VGHUST105-G6-1-1
6 · The paper itself

Abstract

In this paper, a nanobiosensor with surface-enhanced Raman scattering (SERS) capability is introduced for highly sensitive miRNA detection in colorectal cancer. This sensor was designed and fabricated by employing a nanoshielding mechanism from nanopolystyrene beads to resist reactive ion etching and allow anisotropic electrochemical etching, producing high-aspect-ratio, surface-corrugated nanopillars (SiNPs) on a silicon wafer to create extensive hot spots along the nanopillars for improved SERS signals. SERS enhancements were correlated with nanorange roughness, indicating that hot spots along the pillars were the crucial factor to improve the SERS effect. We achieved the detection capability of a trace amount of R6G (10

Indexed as

Biosensing TechniquesMetal NanoparticlesSpectrum Analysis, RamanColorectal NeoplasmsGoldHumansLimit of DetectionMicroRNAsSiliconSurface PropertiesGoldMicroRNAsSiliconcorrugated nanopillarshigh-aspect-ratio nanostructuresmiRNA detectionnanobiosensorSERS

Identifiers

PMID33142781
PMCPMC7692079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.