Evidence map›Paper›PMID 33142747›Full record

ArticleViruses2020

Plaque Reduction Neutralization Test (PRNT) in the Congenital Zika Syndrome: Positivity and Associations with Laboratory, Clinical, and Imaging Characteristics.

Marizélia R C Ribeiro, Ricardo Khouri, Patrícia S Sousa, Maria R F C Branco, Rosângela F L Batista, Elaine P F Costa, Maria T S S B Alves, Gláucio A Amaral, Marcella C R Borges, Eliana H M Takahasi and 7 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Marizélia R C RibeiroDepartment of Medicine III, Federal University of Maranhão, Praça Gonçalves Dias, 21, Centro, São Luís CEP 65020-240, MA, Brazil.
Ricardo KhouriLaboratory of Vector-Borne Infectious Diseases, Gonçalo Moniz Institute, Fiocruz-Bahia, Rua Waldemar Falcão, 121, Candeal, Salvador CEP 40296-710, BA, Brazil.
Patrícia S SousaReference Center on Neurodevelopment, Assistance and Rehabilitation of Children/NINAR- Health Secretariat of the State of Maranhão, Av. dos Holandeses, s/n, São Luís CEP 65077-357, MA, Brazil.
Maria R F C BrancoDepartment of Pathology, Federal University of Maranhão, Praça Madre Deus, 2, Madre Deus, São Luís CEP 65025-560, MA, Brazil.
Rosângela F L BatistaDepartment of Public Health, Federal University of Maranhão, Rua Barão de Itapary, 155, Centro, São Luís CEP 65020-070, MA, Brazil.
Elaine P F CostaDepartment of Medicine I, Federal University of Maranhão, Praça Gonçalves Dias, 21, Centro, São Luís CEP 65020-240, MA, Brazil.
Maria T S S B AlvesDepartment of Public Health, Federal University of Maranhão, Rua Barão de Itapary, 155, Centro, São Luís CEP 65020-070, MA, Brazil.ORCID 0000-0002-4806-7752
Gláucio A AmaralSarah Network of Neurorehabilitation Hospitals, Av. Luis Rocha, s/n, Monte Castelo, São Luís CP 65035-270, MA, Brazil.ORCID 0000-0002-3842-3186
Marcella C R BorgesDiagnostic Imaging Department, Federal University of São Paulo, Rua Napoleão de Barros, 800, São Paulo CEP 04024-002, SP, Brazil.
Eliana H M TakahasiSarah Network of Neurorehabilitation Hospitals, Av. Luis Rocha, s/n, Monte Castelo, São Luís CP 65035-270, MA, Brazil.
Líllian N GomesLaboratory of Human Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1730, Cidade Universitária, São Paulo CEP 05508-900, SP, Brazil.
Ana K T MendesDepartment of Public Health, Federal University of Maranhão, Rua Barão de Itapary, 155, Centro, São Luís CEP 65020-070, MA, Brazil.
Tamires B CavalcanteDepartment of Public Health, Federal University of Maranhão, Rua Barão de Itapary, 155, Centro, São Luís CEP 65020-070, MA, Brazil.ORCID 0000-0002-4063-533X
Luciana C CostaDepartment of Public Health, Federal University of Maranhão, Rua Barão de Itapary, 155, Centro, São Luís CEP 65020-070, MA, Brazil.ORCID 0000-0001-9246-9380
Alvina C FélixLaboratory of Virology, Institute of Tropical Medicine, University of São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 470, São Paulo CEP 05403-000, SP, Brazil.
Nathalia C S SouzaLaboratory of Virology, Institute of Tropical Medicine, University of São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 470, São Paulo CEP 05403-000, SP, Brazil.
Antônio A M SilvaDepartment of Public Health, Federal University of Maranhão, Rua Barão de Itapary, 155, Centro, São Luís CEP 65020-070, MA, Brazil.ORCID 0000-0003-4968-5138
Universidade Federal do Maranhão · BRUniversidade de São Paulo · BRSarah Network of Rehabilitation Hospitals · BRUniversidade Federal da Bahia · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The short duration of viremia, low blood viral load, inaccessibility to timely specific diagnostic tests, and cross-reactions with other flaviviruses have hindered laboratory confirmation of Congenital Zika Syndrome (CZS). This study analyzes the positivity of the plaque reduction neutralization test (PRNT) in children with clinical or imaging characteristics of CZS and its association with laboratory, clinical, and imaging characteristics. The 94 clinical cases of CZS submitted to the ZIKV PRNT

Indexed as

Neutralization TestsViral Plaque AssayBrazilChild, PreschoolClinical Laboratory TechniquesCohort StudiesCross ReactionsFemaleHumansInfantPregnancySerologic TestsTomographyZika Virus Infectionarbovirusbirth defectsCongenital Zika Syndromeinfant healthpregnancy

Identifiers

PMID33142747
PMCPMC7692785
OpenAlexW3095368540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.