Evidence map›Paper›PMID 33142717›Full record

ArticleNutrients2020

Advanced Chronic Kidney Disease with Low and Very Low GFR: Can a Low-Protein Diet Supplemented with Ketoanalogues Delay Dialysis?

Chieh-Li Yen, Pei-Chun Fan, Cheng-Chia Lee, George Kuo, Kun-Hua Tu, Jia-Jin Chen, Tao-Han Lee, Hsiang-Hao Hsu, Ya-Chun Tian, Chih-Hsiang Chang

Abstract readEvaluation Study
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Chronic Kidney Disease: Strategies to Retard Progression.International journal of molecular sciences · 2021
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chieh-Li YenKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33341, Taiwan.
Pei-Chun FanKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33341, Taiwan.
Cheng-Chia LeeKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33341, Taiwan.
George KuoKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33341, Taiwan.
Kun-Hua TuKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33341, Taiwan.
Jia-Jin ChenKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33341, Taiwan.
Tao-Han LeeKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33341, Taiwan.
Hsiang-Hao HsuKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33341, Taiwan.
Ya-Chun TianKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33341, Taiwan.
Chih-Hsiang ChangKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 33341, Taiwan.ORCID 0000-0002-7342-335X

Funding

Chang Gung Memorial Hospital, Linkou CORPG5J0041Ministry of Science and Technology, Taiwan 106-2314-B-182A-118 -MY3Ministry of Science and Technology, Taiwan 109-2314-B-182A-124
6 · The paper itself

Abstract

backgroundPrevious studies have demonstrated that dietary therapy can delay the initiation of dialysis, but little research has investigated whether patients with very poor renal function would benefit from a dietary therapy.

methodsThis study was performed by using the Chang Gung Research Database (CGRD), which is based on the largest medical system in Taiwan. Patients with estimated glomerular filtration rates (eGFR) < 15 mL/min/1.73 m

resultsThe Ketosteril group (

conclusionEven among patients with extremely low eGFR, sLPD treatment can safely delay the need for dialysis.

Indexed as

Dietary SupplementsGlomerular Filtration RateAgedAmino Acids, EssentialDiet, Protein-RestrictedDisease ProgressionFemaleHumansMaleMiddle AgedProportional Hazards ModelsRenal DialysisRenal Insufficiency, ChronicRetrospective StudiesTaiwanTreatment OutcomeAmino Acids, Essentialketosteriladverse eventschronic kidney diseasedialysisKetosterillow-protein diet

Identifiers

PMID33142717
PMCPMC7694025

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.