Evidence map›Paper›PMID 33142714›Full record

ArticleJournal of clinical medicine2020

Associations of HDL Subspecies Defined by ApoC3 with Non-Alcoholic Fatty Liver Disease: The Multi-Ethnic Study of Atherosclerosis.

Jakub Morze, Manja Koch, Sarah A Aroner, Matthew Budoff, Robyn L McClelland, Kenneth J Mukamal, Majken K Jensen

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Jakub MorzeDepartment of Cardiology and Internal Medicine, University of Warmia and Mazury, 11-041 Olsztyn, Poland.ORCID 0000-0002-7119-0273
Manja KochDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-4794-4821
Sarah A AronerDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
Matthew BudoffHarbor-UCLA Medical Center, Los Angeles Biomedical Research Institute, Los Angeles, CA 90095, USA.ORCID 0000-0002-9616-1946
Robyn L McClellandDepartment of Biostatistics, University of Washington, Seattle, WA 98195-7232, USA.
Kenneth J MukamalDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Majken K JensenDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Harvard University · USBeth Israel Deaconess Medical Center · USThe Lundquist Institute · USUniversity of Copenhagen · DKUniversity of Washington · US

Funding

Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
TRAINING GRANT IN ACADEMIC NUTRITIONT32DK007703 · NIDDK · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTOPHER P DUGGAN, Frank B Hu · 1994 to 2026
$7.8M
Ventricular Size and Valve Calcification Measures by CTR01HL071739 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI BUDOFF, MATTHEW J · 2003 to 2010
$2.0M
Non-esterified Fatty Acids and Chronic Pain in Older AdultsK24AG065525 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MUKAMAL, KENNETH JAY · 2020 to 2024
$1.0M
Fetuin-A: A Novel Biomarker of Vascular Calcification and Diabetes MellitusR21HL091217 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IX, JOACHIM H · 2009 to 2010
$608k
Proteomics profiling and risk of dementiaK01AG066817 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI KOCH, MANJA · 2020 to 2021
$226k
American Diabetes Association Research Foundation 1-15-JF-30Deutsche Forschungsgemeinschaft KO 5187/1-1Harvard Medical School William F. Milton FundNCATS NIH HHS UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420NCRR NIH HHS UL1-TR-000040 and UL1-TR-001079NHLBI NIH HHS contracts 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N0NHLBI NIH HHS R01 HL071739NHLBI NIH HHS R21 HL091217NIA NIH HHS K01 AG 066817NIA NIH HHS K01 AG066817NIA NIH HHS K24 AG065525NIDDK NIH HHS T32 DK 007703Novo Nordisk Fonden Challenge Programme: Harnessing the Power of Big Data to Address the Societal Challenge of Aging (grant # NNF17OC0027812)
6 · The paper itself

Abstract

Previously, we reported that inverse associations of high-density lipoprotein (HDL) with cardiovascular disease and diabetes were only observed for HDL that lacked the pro-inflammatory protein apolipoprotein C3 (apoC3). To provide further insight into the cardiometabolic properties of HDL subspecies defined by the presence or absence of apoC3, we aimed to examine these subspecies with liver fat content and non-alcoholic fatty liver disease (NAFLD). We investigated cross-sectional associations between ELISA-measured plasma levels of apoA1 in HDL that contained or lacked apoC3 and computed tomography-determined liver fat content and NAFLD (<51 HU) at baseline (2000-2002) among 5007 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) without heavy alcohol consumption (>14 drinks/week in men and >7 drinks/week in women). In multivariable-adjusted regression models, apoA1 in HDL that contained or lacked apoC3 was differentially associated with liver fat content (

Indexed as

apolipoprotein C3high-density lipoproteinliver fatNAFLD

Identifiers

PMID33142714
PMCPMC7693421
OpenAlexW3095686831

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.