Evidence map›Paper›PMID 33142111›Full record

ReviewCurrent opinion in neurobiology2020

Statistical methods for dissecting interactions between brain areas.

João D Semedo, Evren Gokcen, Christian K Machens, Adam Kohn, Byron M Yu

Open access · hybridAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 87 citations in OpenAlex.

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  9. No Central Executive? Decision Formation Through Multi-Area Population Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

João D SemedoDepartment of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. Electronic address: jsemedo@andrew.cmu.edu.
Evren GokcenDepartment of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. Electronic address: egokcen@cmu.edu.
Christian K MachensChampalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal.
Adam KohnDominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Byron M YuDepartment of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Carnegie Mellon University · USAlbert Einstein College of Medicine · USChampalimaud Foundation · PT

Funding

Shaping Neural Population Dynamics to Facilitate LearningR01HD071686 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BATISTA, AARON PAUL, CHASE, STEVEN M · 2011 to 2021
$3.7M
Computational and Circuit Mechanisms for information transmission in the brainU01NS094288 · NINDS · COLD SPRING HARBOR LABORATORY · PI EDEN, URI TZVI, FRANK, LOREN M · 2015 to 2018
$3.7M
Visual CrowdingR01EY028626 · NEI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KOHN, ADAM · 2018 to 2022
$2.4M
Interrogating and Perturbing Neural DynamicsR01NS105318 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Aaron Paul Batista, Steven M Chase · 2017 to 2026
$2.3M
Slow time scale fluctuations in neurons and behaviorR01MH128393 · NIMH · CARNEGIE-MELLON UNIVERSITY · PI MATTHEW A SMITH · 2022 to 2026
$2.2M
CRCNS: Modulating Neural Population Interactions between Cortical AreasR01MH118929 · NIMH · CARNEGIE-MELLON UNIVERSITY · PI SMITH, MATTHEW A, YU, BYRON M. · 2018 to 2022
$1.7M
Neuronal population dynamics within and across cortical areasR01EB026953 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOIRON, BRENT D., SMITH, MATTHEW A · 2018 to 2020
$1.0M
CRCNS: Interhemispheric coordination for memory and actionR01NS147766 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI Joseph Patrick Mayo, MATTHEW A SMITH · 2025 to 2026
$750k
NEI NIH HHS R01 EY028626NIBIB NIH HHS R01 EB026953NICHD NIH HHS R01 HD071686NIMH NIH HHS R01 MH118929NIMH NIH HHS R01 MH128393NINDS NIH HHS R01 NS105318NINDS NIH HHS R01 NS147766NINDS NIH HHS U01 NS094288
6 · The paper itself

Abstract

The brain is composed of many functionally distinct areas. This organization supports distributed processing, and requires the coordination of signals across areas. Our understanding of how populations of neurons in different areas interact with each other is still in its infancy. As the availability of recordings from large populations of neurons across multiple brain areas increases, so does the need for statistical methods that are well suited for dissecting and interrogating these recordings. Here we review multivariate statistical methods that have been, or could be, applied to this class of recordings. By leveraging population responses, these methods can provide a rich description of inter-areal interactions. At the same time, these methods can introduce interpretational challenges. We thus conclude by discussing how to interpret the outputs of these methods to further our understanding of inter-areal interactions.

Indexed as

BrainNeurons

Identifiers

PMID33142111
PMCPMC7935404
OpenAlexW3097108889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.