Evidence map›Paper›PMID 33142057›Full record

ArticleJournal of medicinal chemistry2020

A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities.

Franck Peiretti, Roberta Montanari, Davide Capelli, Bernadette Bonardo, Cécilia Colson, Ez-Zoubir Amri, Marina Grimaldi, Patrick Balaguer, Keiichi Ito, Robert G Roeder and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Franck PeirettiAix Marseille University, INSERM, INRAE, C2VN, 13385 Marseille, France.ORCID 0000-0001-7198-0534
Roberta MontanariIstituto di Cristallografia, Consiglio Nazionale delle Ricerche, Via Salaria km. 29.300, Monterotondo Stazione, 00015 Rome, Italy.
Davide CapelliIstituto di Cristallografia, Consiglio Nazionale delle Ricerche, Via Salaria km. 29.300, Monterotondo Stazione, 00015 Rome, Italy.
Bernadette BonardoAix Marseille University, INSERM, INRAE, C2VN, 13385 Marseille, France.
Cécilia ColsonUniversité Côte d'Azur, CNRS, Inserm, iBV, 06108 Nice, France.
Ez-Zoubir AmriUniversité Côte d'Azur, CNRS, Inserm, iBV, 06108 Nice, France.
Marina GrimaldiInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM, University of Montpellier, ICM, 34298 Montpellier, France.
Patrick BalaguerInstitut de Recherche en Cancérologie de Montpellier (IRCM), INSERM, University of Montpellier, ICM, 34298 Montpellier, France.
Keiichi ItoLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, United States.
Robert G RoederLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, United States.
Giorgio PochettiIstituto di Cristallografia, Consiglio Nazionale delle Ricerche, Via Salaria km. 29.300, Monterotondo Stazione, 00015 Rome, Italy.ORCID 0000-0002-3980-3180
Jean Michel BrunelAix Marseille University, INSERM, SSA, MCT, 13385 Marseille, France.ORCID 0000-0002-9355-8980
Inserm · FRInstitute of Crystallography · ITCentre National de la Recherche Scientifique · FRRockefeller University · US

Funding

Nuclear Receptor Coactivator Functions and MechanismsR01DK071900 · NIDDK · ROCKEFELLER UNIVERSITY · PI ROEDER, ROBERT G · 2005 to 2015
$5.9M
NIDDK NIH HHS R01 DK071900
6 · The paper itself

Abstract

A proprietary library of novel

Indexed as

AdipocytesAnimalsBinding SitesCell DifferentiationCell LineGlucoseHepatocytesHumansKineticsLipid MetabolismMolecular Docking SimulationPhosphorylationPPAR alphaPPAR gammaProtein BindingRatsGlucosePPAR alphaPPAR gammaValine

Identifiers

PMID33142057
PMCPMC10211484
OpenAlexW3094833453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.