ArticleJCO global oncology2020
Patterns of Early-Onset Colorectal Cancer Among Nigerians and African Americans.
Article in JCO global oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Incidence and risk factors for colorectal cancer in Africa: a systematic review and meta-analysis.BMC gastroenterology · 2024Pooled it
- The burden and histopathological characteristics of early-onset colorectal cancer: a retrospective cross-sectional study at Ethiopia's largest tertiary hospital (2019-2024).International journal of colorectal disease · 2026Article
- Self-identified African ancestry and pathomics-derived tumor-infiltrating lymphocyte scores in colon and rectal adenocarcinoma whole-slide images: an exploratory multicohort whole-slide image study.Frontiers in oncology · 2026Article
- Food Preservatives and the Rising Tide of Early-Onset Colorectal Cancer: Mechanisms, Controversies, and Emerging Innovations.Foods (Basel, Switzerland) · 2025Review
- Rising Incidence and Mortality of Colorectal Cancer in Young African Adults: Need for a Better Care Plan.Cureus · 2025Review
- Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating Occurrence.Cellular and molecular gastroenterology and hepatology · 2025Review
- Cheminformatics-based screening and evaluation of phytochemicals as CDK2 inhibitors in colorectal cancer therapy.PloS one · 2025Article
- Call for intervention and analysis of the rise in young-onset gastrointestinal cancers in low- and middle-income countries: an editorial.Annals of medicine and surgery (2012) · 2024Article
- Early-onset gastrointestinal cancer: An epidemiological reality with great significance and implications.World journal of gastrointestinal oncology · 2024Article
- Survival outcome and prognostic factors for early-onset and late-onset metastatic colorectal cancer: a population based study from SEER database.Scientific reports · 2024Article
- African colorectal cancer burden in 2022 and projections to 2050.Ecancermedicalscience · 2024Article
- Distinct clinical characteristics in stage III rectal cancer among different age groups and treatment outcomes after neoadjuvant chemoradiotherapy.Therapeutic advances in medical oncology · 2024Article
- Molecular genetics of early-onset colorectal cancer.World journal of biological chemistry · 2023Review
- Computational identification of potential inhibitors targetingFrontiers in chemistry · 2023Article
- Genetic insights: High germline variant rate in an indigenous African cohort with early-onset colorectal cancer.Frontiers in oncology · 2023Article
- Colorectal cancer patients in a tertiary hospital in Indonesia: Prevalence of the younger population and associated factors.World journal of clinical cases · 2021Article
- Perioperative and oncologic outcomes in young and octogenarian patients with colorectal cancer: a comparison at the extremes.Langenbeck's archives of surgery · 2021Article
- Disparities in Early-Onset Colorectal Cancer.Cells · 2021Review
- The Effects of Combined Gum-chewing and Parenteral Metoclopramide on the Duration of Postoperative Ileus After Abdominal Surgery.Journal of the West African College of SurgeonsArticle
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeColorectal cancer (CRC) incidence rates are increasing among individuals < 50 years of age (early-onset CRC) globally with causes unknown. Racial/ethnic disparities in early-onset CRC have also grown more pronounced, because Black individuals have higher early-onset CRC incidence and poorer survival compared with White individuals. We describe the prevalence and burden of early-onset CRC among Africans in Nigeria and African Americans (AAs) in the United States. PATIENTS AND
methodsWe identified Black individuals diagnosed with a first primary CRC ages 18 to 49 years between 1989 and 2017 at Ahmadu Bello University Teaching Hospital in Zaria, Nigeria (Nigerians), and in the United States (AAs) using the National Institutes of Health/National Cancer Institute's SEER program of cancer registries. Multivariable logistic regression models were used to investigate clinical and demographic differences between Nigerians and AAs with early-onset CRC, adjusted for age, sex, tumor site, and histology.
resultsA total of 5,019 Black individuals were diagnosed with early-onset CRC over the study period (379 Nigerians; 4,640 AAs). Overall, approximately one third of young Black patients were diagnosed with rectal tumors (35.8%). Nigerian individuals with early-onset CRC were eight-fold more likely to be diagnosed with rectal tumors (odds ratio [OR], 8.14; 95% CI, 6.23 to 10.62;
conclusionCompared with AA individuals diagnosed with early-onset CRC, Nigerian individuals harbor distinct features of early-onset CRC. Additional investigation of the histopathologic and biologic heterogeneity of early-onset CRCs among Black individuals is critical for understanding racial disparities in susceptibility and outcomes, which may have implications for tailored early-onset CRC prevention, detection, and treatment strategies.
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