Evidence map›Paper›PMID 33141601›Full record

ArticleEnvironmental health perspectives2020

Prenatal Metal Mixtures and Birth Weight for Gestational Age in a Predominately Lower-Income Hispanic Pregnancy Cohort in Los Angeles.

Caitlin G Howe, Birgit Claus Henn, Sandrah P Eckel, Shohreh F Farzan, Brendan H Grubbs, Thomas A Chavez, Tahlia L Hodes, Dema Faham, Laila Al-Marayati, Deborah Lerner and 6 more

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Mercury and Prenatal Growth: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
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  13. Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 1 country.

Caitlin G HoweDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Birgit Claus HennDepartment of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Sandrah P EckelDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Shohreh F FarzanDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Brendan H GrubbsDepartment of Obstetrics and Gynecology, Keck School of Medicine, Los Angeles, California, USA.
Thomas A ChavezDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Tahlia L HodesDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Dema FahamDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Laila Al-MarayatiDepartment of Obstetrics and Gynecology, Keck School of Medicine, Los Angeles, California, USA.
Deborah LernerEisner Health, Los Angeles, California, USA.
Alyssa QuimbyDepartment of Obstetrics and Gynecology, Keck School of Medicine, Los Angeles, California, USA.
Sara TwogoodDepartment of Obstetrics and Gynecology, Keck School of Medicine, Los Angeles, California, USA.
Michael J RichardsNSF International, Ann Arbor, Michigan, USA.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Theresa M BastainDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Carrie V BretonDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
University of Southern California · USCedars-Sinai Medical Center · USKeck Graduate Institute · USBoston University · USDartmouth College · USNational Sanitation Foundation International · USUniversity of Michigan · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
Statistical Services and Methods Development ResourceU2CES026555 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2015 to 2025
$26.4M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Untargeted Analysis ResourceU2CES026553 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MEEKER, JOHN D. · 2015 to 2015
$9.5M
Project 2: Environmental Exposures, Stress, and Maternal Pregnancy-Related Weight OutcomesP50ES026086 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M · 2015 to 2019
$3.7M
Development and Testing of Response Surface Methods for Investigating the Epidemiology of Exposure to MixturesR01ES028800 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WEBSTER, THOMAS F · 2018 to 2021
$1.7M
Metal mixtures, children's cognition, and sensitive developmental windowsR00ES022986 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CLAUS HENN, BIRGIT GUNHILD · 2015 to 2017
$747k
Preclinical Indicators & Biomarkers of Cardiovascular Effects of Arsenic ExposureR00ES024144 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FARZAN, SHOHREH F · 2016 to 2018
$746k
Prenatal Metal Mixtures, Fetal Growth, and the Role of MicroRNAsR00ES030400 · NIEHS · DARTMOUTH COLLEGE · PI HOWE, CAITLIN GRACE · 2020 to 2022
$726k
Prenatal Metal Mixtures, Fetal Growth, and the Role of MicroRNAsK99ES030400 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HOWE, CAITLIN GRACE · 2019 to 2020
$202k
NIEHS NIH HHS K99 ES030400NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P50 ES026086NIEHS NIH HHS R00 ES022986NIEHS NIH HHS R00 ES024144NIEHS NIH HHS R00 ES030400NIEHS NIH HHS R01 ES028800NIEHS NIH HHS U2C ES026553NIEHS NIH HHS U2C ES026555NIH HHS UH3 OD023287
6 · The paper itself

Abstract

backgroundReduced fetal growth increases the risk for adverse health outcomes. Growing evidence suggests that metal exposures contribute to reduced fetal growth, but little is known about the effects of complex metal mixtures.

objectivesWe investigated the impact of a complex mixture of metals on birth weight for gestational age (BW for GA) in the Maternal and Developmental Risks from Environmental and Social Stressors study, a predominately lower-income Hispanic pregnancy cohort in Los Angeles, California.

methodsCadmium (Cd), cobalt (Co), mercury (Hg), nickel (Ni), molybdenum (Mo), lead (Pb), antimony (Sb), tin (Sn), and thallium (Tl) were measured by inductively coupled plasma mass spectrometry (ICP-MS) in maternal urine samples collected in early pregnancy (median GA: 13.1 wk). Speciated urinary arsenic (As) (

resultsIn primary analyses, Hg and Ni ranked highest as predictors of BW for GA. An inverse linear association was estimated for Hg, whereas a positive association was estimated for Ni at low-to-moderate concentrations. A potential interaction between Hg and Ni was also identified. In our exploratory analysis, Sb ranked highest as a predictor of BW for GA, followed by Hg and Ni.

conclusionsOur findings suggest that in this understudied population, Hg may reduce fetal growth, whereas Ni may promote fetal growth. We also identified Sb as a potential metal of concern for this population, which merits additional investigation. https://doi.org/10.1289/EHP7201.

Indexed as

Birth WeightAdultBayes TheoremCohort StudiesEnvironmental PollutantsFemaleGestational AgeHispanic or LatinoHumansLos AngelesMaleMaternal ExposureMetalsPregnancyEnvironmental PollutantsMetals

Identifiers

PMID33141601
PMCPMC7608819
OpenAlexW3096781849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.