Evidence map›Paper›PMID 33141576›Full record

ArticleOrganic letters2020

Synthesis of Enantiopure Triols from Racemic Baylis-Hillman Adducts Using a Diastereoselective Peroxidation Reaction.

Dylan S Zuckerman, K A Woerpel

Abstract read
In one paragraph

Article in Organic letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dylan S ZuckermanDepartment of Chemistry, New York University, New York, New York 10003, United States.ORCID 0000-0002-2269-9372
K A WoerpelDepartment of Chemistry, New York University, New York, New York 10003, United States.ORCID 0000-0002-8515-0301

Funding

New Methods for the Synthesis of Biologically Active PeroxidesR01GM118730 · NIGMS · NEW YORK UNIVERSITY · PI WOERPEL, KEITH ALLEN · 2017 to 2020
$1.3M
Acquisition of a Cryoprobe for a 600 MHz NMR SpectrometerS10OD016343 · OD · NEW YORK UNIVERSITY · PI KROGSGAARD, MICHELLE, TRAASETH, NATHANIEL J. · 2014 to 2014
$360k
NIGMS NIH HHS R01 GM118730NIH HHS S10 OD016343
6 · The paper itself

Abstract

Using a chiral (-)-menthone auxiliary, enantiopure cyclic derivatives of Baylis-Hillman adducts were synthesized. A diastereoselective peroxidation reaction was used to introduce an oxygen atom and establish another stereocenter. The resulting products could be elaborated by employing a one-flask reduction-acetylation protocol followed by a diastereoselective nucleophilic substitution reaction. Removal of the (-)-menthone auxiliary provided an enantiopure triol with a structure related to naturally occurring polyols.

Indexed as

Molecular StructurePeroxiredoxinsStereoisomerismPeroxiredoxins

Identifiers

PMID33141576
PMCPMC7680403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.