ReviewHead and neck pathology2021
SMARCB1/INI1 Deficient Sino-Nasal Carcinoma: Extending the Histomorphological Features.
Review in Head and neck pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Integrative Transcriptomics and Machine Learning Reveal the Association of CBX4 with Inflammation in Ulcerative Colitis as a Potential Epigenetic Regulator.Biomedicines · 2026Article
- Interpretable clinical-radiomics fusion model for noninvasive prediction of INI1 deficiency and prognosis in sinonasal undifferentiated carcinoma (SNUC): a two-center study.BMC medical imaging · 2026Article
- SMARCB1 (INI1)-deficient sinonasal carcinoma with yolk sac differentiation, a case of long-term clinical remission after multiple rounds of radiotherapy-a case report and literature review.Diagnostic pathology · 2025Review
- Switch/Sucrose Non-Fermentable (SWI/SNF) Complex-Partial Loss in Sinonasal Squamous Cell Carcinoma: A High-Grade Morphology Impact and Progression.Current issues in molecular biology · 2024Article
- Neuroendocrine and undifferentiated sinonasal and skull base tumors: An up-to-date narrative review.Oral and maxillofacial surgery · 2024Review
- SMARCB1 (INI-1) deficient sinonasal carcinoma of the right maxillary sinus - A rare entity.International journal of surgery case reports · 2024Article
- Immunotherapy in SMARCB1 (INI-1)-deficient sinonasal carcinoma: Two case reports.World journal of clinical cases · 2023Article
- Clinicopathological features and prognostic outcomes of molecularly defined entities in the new edition of the WHO classification of sinonasal carcinoma.Frontiers in oncology · 2023Review
- SMARCB1 (INI-1)-Deficient Sinonasal Carcinoma: A Systematic Review and Pooled Analysis of Treatment Outcomes.Cancers · 2022Review
- Commentary on: SMARCB1 as a novel diagnostic and prognostic biomarker for osteosarcoma.Bioscience reports · 2022Article
- Proceedings of the North American Society of Head and Neck Pathology, Los Angeles, CA, March 20, 2022: SWI/SNF-deficient Sinonasal Neoplasms: An Overview.Head and neck pathology · 2022Article
- Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene.BMC cancer · 2021Article
- SMARCB1-deficient sinonasal carcinoma: a case report and literature review.Journal of surgical case reports · 2021Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SMARCB1/INI1 deficient sinonasal carcinoma is a variant of sinonasal undifferentiated carcinoma (SNUC). There is a paucity of literature describing the histomorphological features of this relatively new entity. Herein we describe the histomorphological features of three such cases and review the literature. We retrospectively reviewed the cases of SNUC diagnosed in our institute in the last 6 years. Immunohistochemistry for INI1, NUT & p16 were performed on these cases. Three cases showed loss of INI1. The histomorphology and clinicopathological features of these cases were studied and compared with non INI1 deficient SNUC. A total of 9 cases of SNUC were identified. Three of these cases showed loss of INI1. These three cases had presented with large sinonasal mass and with intracranial extension. Histopathology of these cases showed a diffuse infiltrative pattern, nest, and islands of predominantly basaloid cells with focal rhabdoid morphology. Additional features like small cell carcinoma like pattern, pseudoalveolar and pseudoglandular patterns, clear vacuoles and pseudopapillary appearance were also noted. We conclude that in presence of a mixed pattern of cells with a predominance of basaloid morphology, the possibility of SMARCB1/INI1 deficient sinonasal carcinoma must be strongly suspected and immunohistochemistry for INI1 must be performed.
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