Evidence map›Paper›PMID 33141311›Full record

ReviewCellular and molecular life sciences : CMLS2021

Regulation of peroxisomal trafficking and distribution.

Christian Covill-Cooke, Viktoriya S Toncheva, Josef T Kittler

Open access · hybridAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. The peroxisome: an update on mysteries 3.0.Histochemistry and cell biology · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Determinants of Peroxisome Membrane Dynamics.Frontiers in physiology · 2022
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Christian Covill-CookeDepartment of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.ORCID http://orcid.org/0000-0002-4479-8734
Viktoriya S TonchevaDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, UK.ORCID http://orcid.org/0000-0002-8526-080X
Josef T KittlerDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, UK. j.kittler@ucl.ac.uk.ORCID http://orcid.org/0000-0002-3437-9456
University College London · GBUniversity of Oxford · GB

Funding

European Research Council 282430Medical Research Council G0802377Medical Research Council MR/N025644/1Medical Research Council (UK) 1368635Medical Research Council (UK) 2180679Medical Research Council (UK) G0802377Medical Research Council (UK) MR/N025644/1
6 · The paper itself

Abstract

Peroxisomes are organelles that perform a wide range of essential metabolic processes. To ensure that peroxisomes are optimally positioned in the cell, they must be transported by both long- and short-range trafficking events in response to cellular needs. Here, we review our current understanding of the mechanisms by which the cytoskeleton and organelle contact sites alter peroxisomal distribution. Though the focus of the review is peroxisomal transport in mammalian cells, findings from flies and fungi are used for comparison and to inform the gaps in our understanding. Attention is given to the apparent overlap in regulatory mechanisms for mitochondrial and peroxisomal trafficking, along with the recently discovered role of the mitochondrial Rho-GTPases, Miro, in peroxisomal dynamics. Moreover, we outline and discuss the known pathological and pharmacological conditions that perturb peroxisomal positioning. We conclude by highlighting several gaps in our current knowledge and suggest future directions that require attention.

Indexed as

Mitochondrial DynamicsAnimalsBiological TransportHumansMicrotubulesMitochondriaMitochondrial ProteinsModels, BiologicalPeroxisomesrho GTP-Binding ProteinsMitochondrial Proteinsrho GTP-Binding ProteinsRHOT1 protein, humanActinDiseaseDyneinKinesinMicrotubule

Identifiers

PMID33141311
PMCPMC7966214
OpenAlexW3095512444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.