Evidence map›Paper›PMID 33141304›Full record

ArticleLung2020

Obstructive Sleep Apnea Severity, Body Mass Index, and Circulating Levels of Cellular Adhesion Molecules.

Bernardo U Peres, A J Hirsch Allen, Tetyana Kendzerska, Aditi Shah, Nurit Fox, Ismail Laher, Fernanda Almeida, Rachel Jen, Andrew J Sandford, Stephan F van Eeden and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Circulating C-reactive protein levels in patients with suspected obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Bernardo U PeresDepartment of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
A J Hirsch AllenDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada, V5Z 1M9, BC, 2775 Laurel Street, 7th Floor.
Tetyana KendzerskaDepartment of Medicine, Division of Respirology, University of Ottawa, Ottawa, Canada.
Aditi ShahDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada, V5Z 1M9, BC, 2775 Laurel Street, 7th Floor.
Nurit FoxDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada, V5Z 1M9, BC, 2775 Laurel Street, 7th Floor.
Ismail LaherDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada, V5Z 1M9, BC, 2775 Laurel Street, 7th Floor.
Fernanda AlmeidaDepartment of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Rachel JenDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada, V5Z 1M9, BC, 2775 Laurel Street, 7th Floor.
Andrew J SandfordSt. Paul's Hospital, Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.
Stephan F van EedenSt. Paul's Hospital, Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.
Najib T AyasDepartment of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada, V5Z 1M9, BC, 2775 Laurel Street, 7th Floor. NAyas@providencehealth.bc.ca.ORCID http://orcid.org/0000-0003-2742-6514
University of British Columbia · CAProvidence Health Care · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the relationship between obstructive sleep apnea (OSA) severity, body mass index (BMI), and circulating levels of inflammatory adhesion molecules (intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin).

methodsA cross-sectional clinical cohort study on all consecutive adults referred to the University of British Columbia (UBC) Sleep Laboratory for a polysomnogram (PSG) for suspected OSA provided a morning blood sample. Samples were analyzed with multiplex immune assay (MilliporeSigma, CA) to assess the levels of adhesion molecules.

results488 patients were studied; the majority were male (68%) with a mean age of 50 yrs, mean AHI of 23 events/hour, and mean BMI of 32 kg/m

conclusionsAlthough all three adhesion molecules were associated with BMI, only E-selectin was independently associated with OSA severity. Future studies are needed to determine the clinical significance of the relationship between E-selectin and OSA.

Indexed as

AdultBody Mass IndexCohort StudiesCross-Sectional StudiesE-SelectinFemaleHumansIntercellular Adhesion Molecule-1Linear ModelsMaleMiddle AgedObesityPolysomnographySeverity of Illness IndexSleep Apnea, ObstructiveVascular Cell Adhesion Molecule-1E-SelectinICAM1 protein, humanIntercellular Adhesion Molecule-1SELE protein, humanVascular Cell Adhesion Molecule-1AdultBiomarkersBloodObesityObstructive sleep apnea(OSA)

Identifiers

PMID33141304
OpenAlexW3097657607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.