Evidence map›Paper›PMID 33141145›Full record

ArticleBrain : a journal of neurology2020

Fast high-resolution metabolic imaging of acute stroke with 3D magnetic resonance spectroscopy.

Yao Li, Tianyao Wang, Tianxiao Zhang, Zengping Lin, Yudu Li, Rong Guo, Yibo Zhao, Ziyu Meng, Jun Liu, Xin Yu and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain : a journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 44 citations in OpenAlex.

  1. Trial
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  6. Review
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  10. Added Value of Sodium MR Imaging and Proton MR Spectroscopy to Conventional MR Imaging for a Better Characterization of the Ischemic Stroke: A Narrative Review.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Accelerated 3D metabolite TMagnetic resonance in medicine · 2024
    Article
  16. High-resolutionNMR in biomedicine · 2024
    Article
  17. Article
  18. Simultaneous high-resolution whole-brain MR spectroscopy and [European journal of nuclear medicine and molecular imaging · 2024
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Yao LiInstitute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Tianyao WangRadiology Department, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Tianxiao ZhangInstitute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Zengping LinInstitute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yudu LiBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Rong GuoBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Yibo ZhaoBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Ziyu MengInstitute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Jun LiuRadiology Department, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Xin YuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Zhi-Pei LiangBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Parashkev NachevHigh-Dimensional Neurology Group, Institute of Neurology, University College London, London, UK.
University of Illinois Urbana-Champaign · USFudan University · CNShanghai Jiao Tong University · CNCase Western Reserve University · USUniversity College London · GB

Funding

Phosphorus-31 MR Spectroscopic Imaging and FingerprintingR01EB023704 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI LIANG, ZHI-PEI, YU, XIN · 2017 to 2020
$1.8M
NIBIB NIH HHS R01 EB023704Wellcome TrustWellcome Trust 213038/Z/18/Z
6 · The paper itself

Abstract

Impaired oxygen and cellular metabolism is a hallmark of ischaemic injury in acute stroke. Magnetic resonance spectroscopic imaging (MRSI) has long been recognized as a potentially powerful tool for non-invasive metabolic imaging. Nonetheless, long acquisition time, poor spatial resolution, and narrow coverage have limited its clinical application. Here we investigated the feasibility and potential clinical utility of rapid, high spatial resolution, near whole-brain 3D metabolic imaging based on a novel MRSI technology. In an 8-min scan, we simultaneously obtained 3D maps of N-acetylaspartate and lactate at a nominal spatial resolution of 2.0 × 3.0 × 3.0 mm3 with near whole-brain coverage from a cohort of 18 patients with acute ischaemic stroke. Serial structural and perfusion MRI was used to define detailed spatial maps of tissue-level outcomes against which high-resolution metabolic changes were evaluated. Within hypoperfused tissue, the lactate signal was higher in areas that ultimately infarcted compared with those that recovered (P < 0.0001). Both lactate (P < 0.0001) and N-acetylaspartate (P < 0.001) differed between infarcted and other regions. Within the areas of diffusion-weighted abnormality, lactate was lower where recovery was observed compared with elsewhere (P < 0.001). This feasibility study supports further investigation of fast high-resolution MRSI in acute stroke.

Indexed as

AdultAgedAged, 80 and overAspartic AcidCohort StudiesFemaleHumansImage Processing, Computer-AssistedImaging, Three-DimensionalIschemic StrokeLactic AcidMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedNeuroimagingAspartic AcidLactic AcidN-acetylaspartateSpin Labelsischaemic strokelactatemagnetic resonance spectroscopic imagingN-acetylaspartatepenumbra

Identifiers

PMID33141145
PMCPMC7719019
OpenAlexW3097276416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.