Evidence map›Paper›PMID 33140978›Full record

ArticleInhalation toxicology

Characterization of E-cigarette coil temperature and toxic metal analysis by infrared temperature sensing and scanning electron microscopy - energy-dispersive X-ray.

Haley A Mulder, James B Stewart, Ivy P Blue, Rose I Krakowiak, Jesse L Patterson, Kimberly N Karin, Jasmynne M Royals, Alexandra C DuPont, Kaitlin E Forsythe, Justin L Poklis and 4 more

Abstract read
In one paragraph

Article in Inhalation toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Toxicity and Appeal of Flavoured E-Cigarettes and Flavour Ban Outcomes: A Narrative Review.International journal of environmental research and public health · 2026
    Review
  4. Review
  5. Chemical Analysis and Flavor Distribution of Electronic Cigarettes in Australian Schools.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. E-Cigarette Toxicology.Annual review of pharmacology and toxicology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Haley A MulderDepartment of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
James B StewartDepartment of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Ivy P BlueDepartment of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Rose I KrakowiakDepartment of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Jesse L PattersonDepartment of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Kimberly N KarinDepartment of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Jasmynne M RoyalsDepartment of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Alexandra C DuPontDepartment of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Kaitlin E ForsytheDepartment of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Justin L PoklisDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.ORCID 0000-0001-5470-5717
Alphonse PoklisDepartment of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Shelle N ButlerDepartment of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Joseph B McGee TurnerDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA, USA.
Michelle R PeaceDepartment of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.

Funding

VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI JOLENE J WINDLE · 2014 to 2026
$13.8M
BLRD VA I01 BX000150NIDA NIH HHS P30 DA033934
6 · The paper itself

Abstract

introductionElectronic cigarettes (e-cigarettes) have rapidly evolved since their introduction to the U.S. market. The rebuildable atomizer (RBA) offers user-driven modification to the heating element (coil) and wicking systems. Different coil materials can be chosen based on user needs and preferences. However, the heating element of an e-cigarette is believed to be one-source for toxic metal exposure.

methodsE-cigarette coils from Kanthal and nichrome wires were constructed in a contact and non-contact configuration and heated at four voltages. The maximum temperatures of the coils were measured by infrared temperature sensing when dry and when saturated with 100% vegetable glycerin or 100% propylene glycol. The metal composition of each coil was analyzed with Scanning Electron Microscopy-Energy-Dispersive X-Ray (SEM-EDX) when new, and subsequently after 1, 50, and 150 heat cycles when dry.

resultsThe coils reached temperatures above 1000 °C when dry, but were below 300 °C in both liquid-saturated mediums. Metal analysis showed a decrease of 9-19% chromium and 39-58% iron in Kanthal wire and a decrease of 12-14% iron and 39-43% nickel in nichrome wire after 150 heat cycles. Significant metal loss was observed after one heat cycle for both coil alloys and configurations.

conclusionsThe loss of metals from these heat cycles further suggests that the metals from the coils are potentially entering the aerosol of the e-cigarette, which can be inhaled by the user.

Indexed as

Electronic Nicotine Delivery SystemsInfrared RaysMetals, HeavyMicroscopy, Electron, ScanningTemperatureX-RaysMetals, HeavycoilsE-cigarettesmetal aerosolmetal analysisSEM-EDX

Identifiers

PMID33140978
PMCPMC8846427

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.