ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2021
Chondrocyte-to-osteoblast transformation in mandibular fracture repair.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Dorsal Root Ganglion-Targeted DNA Origami Delivery of IL1RN for Skeletal Growth and Repair.Pharmaceutics · 2026Article
- METTL3-mediated m6A methylation to promote mandibular condyle fracture repair via TGF-β/Smad signaling pathway.Scientific reports · 2026Article
- Chondrogenic Potential of Periosteum-Derived Cells.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026Article
- Microenvironment-mediated stem cell fate in periodontal tissue remodeling and repair.Bioactive materials · 2026Review
- Communication between endothelial cells and osteoblasts in regulation of bone homeostasis: Notch players.Stem cell research & therapy · 2025Review
- Deep behavioral phenotyping tracks functional recovery following tibia fracture in mice.Frontiers in physiology · 2025Article
- Beyond bone volume: Understanding tissue-level quality in healing of maxillary vs. femoral defects.Acta biomaterialia · 2024Article
- Bone Development and Growth.International journal of molecular sciences · 2024Article
- The Contribution of Meckel's Cartilage-Derived Type II Collagen-Positive Cells to the Jawbone Development and Repair.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024Article
- Biomechanical Effects of Mechanical Stress on Cells Involved in Fracture Healing.Orthopaedic surgery · 2024Review
- Interfacial Tissue Regeneration with Bone.Current osteoporosis reports · 2024Review
- Chondrocytes supplemented to bone graft-containing scaffolds expedite cranial defect repair.Scientific reports · 2023Article
- Sequential application of small molecule therapy enhances chondrogenesis and angiogenesis in murine segmental defect bone repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Liraglutide in Combination with Insulin Has a Superior Therapeutic Effect to Either Alone on Fracture Healing in Diabetic Rats.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Uncovering the unique characteristics of the mandible to improve clinical approaches to mandibular regeneration.Frontiers in physiology · 2023Review
- Article
- A Shifting Paradigm: Transformation of Cartilage to Bone during Bone Repair.Journal of dental research · 2023Review
- The role of hypertrophic chondrocytes in regulation of the cartilage-to-bone transition in fracture healing.Bone reports · 2022Article
- The Emerging Role of Cell Transdifferentiation in Skeletal Development and Diseases.International journal of molecular sciences · 2022Review
- Notch signaling enhances bone regeneration in the zebrafish mandible.Development (Cambridge, England) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The majority of fracture research has been conducted using long bone fracture models, with significantly less research into the mechanisms driving craniofacial repair. However, craniofacial bones differ from long bones in both their developmental mechanism and embryonic origin. Thus, it is possible that their healing mechanisms could differ. In this study we utilize stabilized and unstabilized mandible fracture models to investigate the pathways regulating repair. Whereas fully stable trephine defects in the ramus form bone directly, mechanical motion within a transverse fracture across the same anatomical location promoted robust cartilage formation before boney remodeling. Literature investigating long bone fractures show chondrocytes are a direct precursor of osteoblasts during endochondral repair. Lineage tracing with Aggrecan-Cre
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.