Evidence map›Paper›PMID 33140723›Full record

ArticleeLife2020

Walking

Mahmut Demir, Nirag Kadakia, Hope D Anderson, Damon A Clark, Thierry Emonet

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Fly navigational responses exploit plume-specific odor motion and gradient cues.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Optogenetic Analysis of Behavior in the MosquitobioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Mice navigate scent trails using predictive policies.bioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Inhibitory control explains locomotor statistics in walkingProceedings of the National Academy of Sciences of the United States of America · 2025
    Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Mahmut Demir *Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0002-3278-7843
Nirag Kadakia *Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0001-9978-6450
Hope D AndersonDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.
Damon A ClarkDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0001-8487-700X
Thierry EmonetDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.ORCID 0000-0002-6746-6564

Funding

Integrating visual counterevidence to detect self-motion in a small visual circuitR01EY026555 · NEI · YALE UNIVERSITY · PI CLARK, DAMON ALISTAIR · 2016 to 2025
$4.0M
The contribution of phenotypic variability to chemotactic performanceR01GM106189 · NIGMS · YALE UNIVERSITY · PI EMONET, THIERRY · 2013 to 2022
$2.6M
KITP Interdisciplinary Biology InitiativeR25GM067110 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SHRAIMAN, BORIS I · 2003 to 2018
$1.8M
Quantifying the role of adaptation in olfactory coding through the logic of navigationF32MH118700 · NIMH · YALE UNIVERSITY · PI KADAKIA, NIRAG · 2018 to 2021
$207k
Allen Foundation 11562Gordon and Betty Moore Foundation 2919.02National Science Foundation DBI-1755494National Science Foundation PHY-1748958NEI NIH HHS R01 EY026555NIGMS NIH HHS R01 GM106189NIGMS NIH HHS R25 GM067110NIMH NIH HHS F32 MH118700
6 · The paper itself

Abstract

How insects navigate complex odor plumes, where the location and timing of odor packets are uncertain, remains unclear. Here we imaged complex odor plumes simultaneously with freely-walking flies, quantifying how behavior is shaped by encounters with individual odor packets. We found that navigation was stochastic and did not rely on the continuous modulation of speed or orientation. Instead, flies turned stochastically with stereotyped saccades, whose direction was biased upwind by the timing of prior odor encounters, while the magnitude and rate of saccades remained constant. Further, flies used the timing of odor encounters to modulate the transition rates between walks and stops. In more regular environments, flies continuously modulate speed and orientation, even though encounters can still occur randomly due to animal motion. We find that in less predictable environments, where encounters are random in both space and time, walking flies navigate with random walks biased by encounter timing.

Indexed as

OdorantsAnimalsArthropod AntennaeBehavior, AnimalDecision MakingDrosophila melanogasterFlight, AnimalNormal DistributionOrientationStochastic ProcessesWalkingD. melanogasternavigationneuroscienceodor plumesolfactionolfactory searchphysics of living systemsturbulencewind tunnel

Identifiers

PMID33140723
PMCPMC7609052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.