Evidence map›Paper›PMID 33140695›Full record

ArticleJournal of biomolecular structure & dynamics2022

Computer aided identification of potential SARS CoV-2 main protease inhibitors from diterpenoids and biflavonoids of

Rajesh Ghosh, Ayon Chakraborty, Ashis Biswas, Snehasis Chowdhuri

Open access · greenAbstract read
In one paragraph

Article in Journal of biomolecular structure & dynamics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Informatics in medicine unlocked · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Identification of Alkaloids fromChemistrySelect · 2022
    Article
  10. Inhibition of the main protease of SARS-CoV-2 (MComputational and structural biotechnology journal · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Identification of (2RSC advances · 2021
    Article
  15. Review
  16. An overview of potential inhibitors targeting non-structural proteins 3 (PLComputational and structural biotechnology journal · 2021
    Review
  17. Journal of advanced pharmaceutical technology & research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rajesh GhoshSchool of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, India.
Ayon ChakrabortySchool of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, India.ORCID 0000-0002-1155-7862
Ashis BiswasSchool of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, India.
Snehasis ChowdhuriSchool of Basic Sciences, Indian Institute of Technology Bhubaneswar, Bhubaneswar, India.
Indian Institute of Technology Bhubaneswar · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS CoV-2 is the causative agent of the pandemic disease COVID-19. There is an urgent need for effective drugs or vaccines which can effectively combat this outbreak. The main protease (Mpro), a key component for the SARS CoV-2 replication, is considered to be one of the important drug targets for developing anti-COVID-19 drugs. This SARS CoV-2 Mpro/cysteine protease has high sequence similarity with the same protease from SARS CoV-1. Previously, it has been shown experimentally that eight diterpenoids and four biflavonoids derived from the leaf of

Indexed as

BiflavonoidsCOVID-19 Drug TreatmentDiterpenesTaxaceaeComputersHumansMolecular Docking SimulationPlant LeavesProtease InhibitorsBiflavonoidsDiterpenesProtease InhibitorsCOVID-19dockingmolecular dynamics simulationSARS CoV-2 main proteaseTorreya nucifera diterpenoids and biflavonoids

Identifiers

PMID33140695
PMCPMC7663460
OpenAlexW3094951777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.