ArticleAutism research : official journal of the International Society for Autism Research2021
Prolonged Auditory Brainstem Response in Universal Hearing Screening of Newborns with Autism Spectrum Disorder.
Article in Autism research : official journal of the International Society for Autism Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- A Systematic Review of Brainstem Contributions to Autism Spectrum Disorder.Frontiers in integrative neuroscience · 2021Pooled it
- Task force Guideline of Brazilian Society of Otology ‒ hearing loss in children - Part I ‒ Evaluation.Brazilian journal of otorhinolaryngologyGuideline
- Infant sensory gating and a developmental cascade to autistic traits and anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Early neurophysiological markers of aberrant auditory processing associated with increased risk of autism spectrum disorder: A systematic review.Pediatric investigation · 2025Review
- Acoustic Exaggeration Enhances Speech Discrimination in Young Autistic Children.Autism research : official journal of the International Society for Autism Research · 2025Article
- Autism Spectrum Disorder in Children: Early Signs and Therapeutic Interventions.Children (Basel, Switzerland) · 2024Review
- Age-dependent deficits of auditory brainstem responses in juvenile Neurexin1α knockout rats.Scientific reports · 2024Article
- Cortical dysmorphology and reduced cortico-collicular projections in an animal model of autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Habituation of auditory responses in young autistic and neurotypical children.Autism research : official journal of the International Society for Autism Research · 2023Article
- The prevalence and developmental course of auditory processing differences in autistic children.Autism research : official journal of the International Society for Autism Research · 2023Article
- Prediction of autism in infants: progress and challenges.The Lancet. Neurology · 2023Review
- Brainstem auditory physiology in children with listening difficultiesHearing research · 2023Article
- Sensing echoes: temporal misalignment in auditory brainstem responses as the earliest marker of neurodevelopmental derailment.PNAS nexus · 2023Article
- Newborn Auditory Brainstem Responses in Children with Developmental Disabilities.Journal of autism and developmental disorders · 2023Article
- Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3.iScience · 2022Article
- Non-Apoptotic Caspase Activity Preferentially Targets a Novel Consensus Sequence Associated With Cytoskeletal Proteins in the Developing Auditory Brainstem.Frontiers in cell and developmental biology · 2022Article
- Optimal time lags from causal prediction model help stratify and forecast nervous system pathology.Scientific reports · 2021Article
- A review of decreased sound tolerance in autism: Definitions, phenomenology, and potential mechanisms.Neuroscience and biobehavioral reviews · 2021Review
- Central Auditory and Vestibular Dysfunction Are Key Features of Autism Spectrum Disorder.Frontiers in integrative neuroscience · 2021Article
- The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers.Frontiers in integrative neuroscience · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Previous studies report prolonged auditory brainstem response (ABR) in children and adults with autism spectrum disorder (ASD). Despite its promise as a biomarker, it is unclear whether healthy newborns who later develop ASD also show ABR abnormalities. In the current study, we extracted ABR data on 139,154 newborns from their Universal Newborn Hearing Screening, including 321 newborns who were later diagnosed with ASD. We found that the ASD newborns had significant prolongations of their ABR phase and V-negative latency compared with the non-ASD newborns. Newborns in the ASD group also exhibited greater variance in their latencies compared to previous studies in older ASD samples, likely due in part to the low intensity of the ABR stimulus. These findings suggest that newborns display neurophysiological variation associated with ASD at birth. Future studies with higher-intensity stimulus ABRs may allow more accurate predictions of ASD risk, which could augment the universal ABR test that currently screens millions of newborns worldwide. LAY SUMMARY: Children with autism spectrum disorder (ASD) have slow brain responses to sounds. We examined these brain responses from newborns' hearing tests and found that newborns who were later diagnosed with autism also had slower brain responses to sounds. Future studies might use these findings to better predict autism risk, with a hearing test that is already used on millions of newborns worldwide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.