Evidence map›Paper›PMID 33140460›Full record

ArticleDrug and alcohol review2021

The acute and repeated effects of cigarette smoking and smoking-related cues on impulsivity.

Suky Martinez, Jermaine D Jones, Nehal P Vadhan, Laura Brandt, Sandra D Comer, Adam Bisaga

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01395797 (Effects of Pioglitazone, a PPARγ Agonist, on the Abuse Liability of Heroin and of Nicotine), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01395797 phase1 / phase2terminatednot on this map

Effects of Pioglitazone, a PPARγ Agonist, on the Abuse Liability of Heroin and of Nicotine

TypeinterventionalSponsorNew York State Psychiatric InstituteRan2011 to 2014Enrolled82ConditionsHeroin Dependence, Nicotine DependenceArmsPIO, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Suky MartinezDivision on Substance Use Disorders, New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, USA.ORCID 0000-0002-4873-8130
Jermaine D JonesDivision on Substance Use Disorders, New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, USA.
Nehal P VadhanDepartments of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra University/Northwell Health, Hempstead, USA.
Laura BrandtDivision on Substance Use Disorders, New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, USA.
Sandra D ComerDivision on Substance Use Disorders, New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, USA.
Adam BisagaDivision on Substance Use Disorders, New York State Psychiatric Institute, Columbia University Irving Medical Center, New York, USA.
New York Psychoanalytic Society and Institute · USCity College of New York · USNorthwell Health · US

Funding

Translational Clinical Research Fellowship on Substance Use DisordersT32DA007294 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Frances Rudnick Levin, Diana M Martinez · 1993 to 2026
$9.3M
Translational Research Training on Addictions for Racial/Ethnic MinoritiesR25DA035161 · NIDA · CITY COLLEGE OF NEW YORK · PI DENISE AIMEE HIEN, Lesia Monique Ruglass · 2013 to 2026
$4.4M
Pioglitazone for the Treatment of Opioid and of Nicotine DependenceR01DA031022 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BISAGA, ADAM, COMER, SANDRA D · 2010 to 2013
$3.5M
NIDA NIH HHS R01 DA031022NIDA NIH HHS R25 DA035161NIDA NIH HHS T32 DA007294
6 · The paper itself

Abstract

INTRODUCTION AND

aimsImpulsivity may be a risk factor that increases vulnerability to nicotine dependence. However, nicotine exposure itself may directly increase impulsivity. This is a secondary analysis of the first study in a controlled laboratory setting, which assessed the effects of nicotine administration (acute and repeated) and exposure to smoking cues on behavioural impulsivity in humans (ClinicalTrials.gov Identifier: NCT01395797). DESIGN AND

methodsTwenty-seven smokers completed three tasks to assess behavioural impulsivity (the Immediate Memory Task and the Delayed Memory Task assessing response initiation, and the GoStop Task assessing response inhibition) following: (i) 4 days of cigarette smoking (nicotinised or denicotinised cigarette); (ii) acute cigarette smoking (nicotinised); and (iii) exposure to smoking-related cues.

resultsFour days of nicotinised cigarette smoking (vs. denicotinised) did not significantly increase Immediate Memory Task, Delayed Memory Task and GoStop scores. However, acute cigarette smoking increased GoStop impulsivity, but only following 4 days of smoking nicotinised cigarettes (P < 0.05). Exposure to smoking-related cues had no statistically significant effect on impulsivity. DISCUSSION AND

conclusionsOur results suggest that repeated nicotine exposure may sensitise subsequent acute nicotine effects on behavioural impulsivity in heavy smokers.

Indexed as

Cigarette SmokingTobacco Use DisorderCuesHumansImpulsive BehaviorSmokingcue reactivityimpulsivitynicotinerandomised controlled trialsmoking

Identifiers

PMID33140460
PMCPMC8088442
OpenAlexW3096352124

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.