ArticleCardiology journal2022
Lymphopenia and mortality among patients undergoing coronary angiography: Long-term follow-up study.
Article in Cardiology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Pan-immune-inflammation value for risk stratification of adverse cardiovascular outcomes in acute coronary syndrome undergoing percutaneous coronary intervention: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- The C-reactive protein-albumin-lymphocyte (CALLY) index as a predictor of mortality in patients undergoing carotid artery stenting.Irish journal of medical science · 2026Article
- The Osaka Prognostic Score as a Novel Predictor of Contrast-Induced Nephropathy and In-Hospital Mortality in STEMI Patients Undergoing Primary Percutaneous Coronary Intervention.Acta Cardiologica Sinica · 2026Article
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- Association of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios With Three-Vessel Coronary Artery Disease: A Case-Control Study.Health science reports · 2026Article
- Specific Deficiency of Naïve CD4+ T Lymphocytes Characterizes Heart Failure and Heightens Mortality Risk in the HRS.Journal of the American Heart Association · 2026Article
- The neutrophil-to-lymphocyte ratio as a marker of immunosenescence and COVID-19 outcomes in the elderly: A narrative review.Physiological reports · 2026Review
- Is the Cally index truly a prognostic marker that predicts mortality in older patients with acute coronary syndrome?Frontiers in cardiovascular medicine · 2026Article
- HDL-Adjusted Inflammatory Ratios and Sequential Graft Configuration are Associated with Mid-Term Saphenous Vein Graft Occlusion in a Post-CABG Angiography Cohort.Journal of inflammation research · 2026Article
- Osaka Prognostic Score Predicts In-Hospital and One-Year Mortality Following Transcatheter Aortic Valve Implantation.Medicina (Kaunas, Lithuania) · 2025Article
- Associations between the Platelet Lymphocyte Ratio and Albumin with Plaque Calcification in Patients with Acute Coronary Syndrome: An Optical Coherence Tomography Study.Reviews in cardiovascular medicine · 2025Article
- Associations between neutrophil-lymphocyte ratio with all-cause mortality, major adverse vascular events and progression of diabetic kidney disease in type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- Lymphocyte-to-Red Blood Cell Ratio-The Guide Star of Acute Coronary Syndrome Prognosis.Healthcare (Basel, Switzerland) · 2024Article
- Article
- Predictors of Carbohydrate Metabolism Disorders and Lethal Outcome in Patients after Myocardial Infarction: A Place of Glucose Level.Journal of personalized medicine · 2023Article
- Health-Related Quality of Life and Influencing Factors in Coronary Heart Disease Based on the Scale QLICD-CHD (V2.0): A Cross-Sectional Study.International journal of general medicine · 2023Article
- Discordance Between Neutrophil to Lymphocyte Ratio and High Sensitivity C-Reactive Protein to Predict Clinical Events in Patients with Stable Coronary Artery Disease: A Large-Scale Cohort Study.Journal of inflammation research · 2023Article
- Association of Neutrophil to Lymphocyte Ratio With Plaque Rupture in Acute Coronary Syndrome Patients With Only Intermediate Coronary Artery Lesions Assessed by Optical Coherence Tomography.Frontiers in cardiovascular medicine · 2022Article
- Importance of hematological parameters for micro- and macrovascular outcomes in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study.Cardiovascular diabetology · 2021Observational
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLymphopenia is associated with adverse prognosis in chronic disease states that are related to immune dysregulation. We aimed to determine the association between lymphopenia and mortality in patients presenting to coronary angiography and investigate whether elevated red blood cell distribution width (RDW), an established cardiovascular prognostic marker, further refines risk stratification.
methodsRetrospective analysis of patients undergoing coronary angiography for evaluation or treatment of coronary artery disease between 2003 and 2018. Mortality risk associated with relative (1000-1500/μL) or severe ( < 1000/μL) lymphopenia was analyzed using adjusted Cox proportional hazards regression models.
resultsOverall, 15,179 patients aged 65 ± 12 years underwent coronary angiography. During a median follow-up of 8 years, 4253 patients died. Compared to normal lymphocyte count, the adjusted hazard ratio (HR) for mortality was 1.31 (95% confidence interval [CI] 1.21-1.41) and 1.97 (95% CI 1.75-2.22) for relative and severe lymphopenia, respectively. The increase in mortality associated with severe lymphopenia was significant in patients presenting in the non-acute setting (HR 2.18, 95% CI 1.74-2.73), ST-segment elevation myocardial infarction (STEMI) (HR 1.59, 95% CI 1.15-2.21), or unstable angina/non-STEMI (HR 2.00, 95% CI 1.70-2.34); p-value for interaction 0.626. The association of lymphopenia with mortality remained significant after additional adjustment to RDW. High RDW ( > 14.5%) was associated with reduced survival, and it improved the predictive accuracy of lymphocytes count with an increase in Harrell's Concordance statistic from 0.634 (SE = 0.005) to 0.672 (SE = 0.005), p < 0.001.
conclusionslymphopenia is associated with increased risk of mortality during long-term follow-up in patients undergoing coronary angiography, regardless of the coronary presentation. High RDW may enhance the predictive ability of lymphopenia.
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