Evidence map›Paper›PMID 33140385›Full record

ArticleCardiology journal2022

Clinical characteristics and prognosis of myocardial infarction with non-obstructive coronary arteries: A prospective single-center study.

Javier Lopez-Pais, Bárbara Izquierdo Coronel, David Galán Gil, Maria Jesús Espinosa Pascual, Blanca Alcón Durán, Carlos Gustavo Martinez Peredo, Carlos Moreno Vinués, Paula Awamleh García, Jose Ramón Gonzalez-Juanatey, Javier Muñiz García and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Javier Lopez-PaisCardiology Department, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain. javierlopezpais@gmail.com.ORCID 0000-0001-5511-5954
Bárbara Izquierdo CoronelCardiology Department, Hospital Universitario de Getafe, Madrid, Spain.
David Galán GilCardiology Department, Hospital Universitario de Getafe, Madrid, Spain.
Maria Jesús Espinosa PascualCardiology Department, Hospital Universitario de Getafe, Madrid, Spain.
Blanca Alcón DuránCardiology Department, Hospital Universitario de Getafe, Madrid, Spain.
Carlos Gustavo Martinez PeredoCardiology Department, Hospital Universitario de Getafe, Madrid, Spain.
Carlos Moreno VinuésCardiology Department, Hospital Universitario de Getafe, Madrid, Spain.
Paula Awamleh GarcíaCardiology Department, Hospital Universitario de Getafe, Madrid, Spain.
Jose Ramón Gonzalez-JuanateyCardiology Department, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
Javier Muñiz GarcíaCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Joaquín Jesús Alonso MartínCardiology Department, Hospital Universitario de Getafe, Madrid, Spain.
Hospital Universitario de Getafe · ESCentro de Investigación Biomédica en Red · ESCentro de Investigación en Red en Enfermedades Cardiovasculares · ESComplejo Hospitalario Universitario de Santiago · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA definition of myocardial infarction with non-obstructive coronary arteries (MINOCA) was published by European Society of Cardiology in 2016. The aim of this study is to analyze the clinical profile and prognosis of these patients in a prospective single-center study and compare it with the literature data.

methodsDuring a 3-year period, information from every consecutive MINOCA patient was gathered (n = 109). It was then compared with 412 contemporaneous patients with myocardial infarction and obstructive coronary arteries (MIOCA). Univariate and multivariate analyses were performed. Prognosis analysis was adjusted by age and cardiovascular risk factors (CVRF).

resultsMINOCA represented 16.9% of the total of patients admitted for myocardial infarction (MI). Compared with MIOCA, they had more psychosocial disorders (22.9% vs. 10.7%; p < 0.01) and more pro-inflammatory conditions (34.9% vs. 14.0%; p < 0.01). Atrial fibrillation was twice as frequent in MINOCA (14.7% vs. 7.3%; p = 0.016). Predictors of MINOCA were as follows: female gender, absence of diabetes, absence of tobacco use, tachycardia, troponin above 10 times the 99th percentile, and proinflammatory conditions. Median follow-up was 17.3 ± 9.3 months. Major adverse cardiovascular events (MACE; a composite of a recurrence of acute MI, transient ischemic attack/stroke, or death from cardiovascular cause and death from any cause) occurred in 10.8% of the MINOCA group as compared with 10.7% in the MIOCA group (hazard ratio [HR] 1.19, 95% confidence interval [CI] 0.58-2.45; p = 0.645). Cardiovascular re-admission rates were higher in the MINOCA group: 19.8% vs. 13.9% (HR 1.85; CI 1.06-3.21; p = 0.030).

conclusionsThe frequency of MINOCA is high, with fewer CVRF, and it is linked to atrial fibrillation, psychosocial disorders, and pro-inflammatory conditions. Mid-term prognosis is worse than previously thought, with a similar proportion of MACE as compared to MIOCA, and even a higher rate of cardiovascular re-admissions.

Indexed as

Atrial FibrillationCoronary Artery DiseaseMyocardial InfarctionCoronary AngiographyCoronary VesselsFemaleHumansMINOCAPrognosisProspective StudiesRisk FactorsTroponinTroponinatrial fibrillationdefinitionmyocardial infarction with non-obstructive coronary arteries (MINOCA)prognosisproinflammatory

Identifiers

PMID33140385
PMCPMC9550329
OpenAlexW3095140331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.