Evidence map›Paper›PMID 33140265›Full record

ArticleHead and neck pathology2021

Epstein-Barr Virus-Associated Langerhans Cell Histiocytosis of the Thyroid Gland.

Jijgee Munkhdelger, Patravoot Vatanasapt, Chamsai Pientong, Somboon Keelawat, Andrey Bychkov

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Jijgee MunkhdelgerDepartment of Pathology, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan.ORCID http://orcid.org/0000-0003-3483-2342
Patravoot VatanasaptDepartment of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.ORCID http://orcid.org/0000-0001-6037-8994
Chamsai PientongHPV and EBV Carcinogenesis Research Group, Khon Kaen University, 40002, Khon Kaen, Thailand.ORCID http://orcid.org/0000-0003-2797-043X
Somboon KeelawatDepartment of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.ORCID http://orcid.org/0000-0002-4180-7914
Andrey BychkovDepartment of Pathology, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan. bychkov.andrey@kameda.jp.ORCID http://orcid.org/0000-0002-4203-5696
Khon Kaen University · THChulalongkorn University · THKameda Medical Center · JPUniversity of Nagasaki · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid gland involvement of Langerhans cell histiocytosis (LCH) is extremely rare in both systemic and isolated disease. The role of viral infection in LCH development is not yet fully understood. Although several viruses are proposed as etiologic factors, such as Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6), they seem to play a bystander role in LCH. A 29-year old female patient with a prior history of multisystemic LCH (pituitary gland and skull bone), presented with a thyroid nodule. The patient underwent a total thyroidectomy and the histological examination revealed nodular lesions composed of sheets and clusters of histiocytes in the inflammatory background. The histiocytes stained positive for S-100 and CD1a and were negative for HHV-8, cytomegalovirus, and VE1 (anti-BRAF

Indexed as

AdultEpstein-Barr Virus InfectionsFemaleHistiocytosis, Langerhans-CellHumansThyroid DiseasesEpstein-Barr virusLangerhans cell histiocytosisThyroid

Identifiers

PMID33140265
PMCPMC8385082
OpenAlexW3095156957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.