ArticleJournal of clinical immunology2021
POLD1 Deficiency Reveals a Role for POLD1 in DNA Repair and T and B Cell Development.
Abstract readCase ReportsLetter
In one paragraph
Article in Journal of clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Structural and functional impact of the POLD1 Ser605del variant in MDPL syndrome: insights from protein-protein interactions.Human genomics · 2025Article
- Human genetic influences on early B cell development.Journal of human immunity · 2025Review
- Replication stress, microcephalic primordial dwarfism, and compromised immunity in ATRIP deficient patients.The Journal of experimental medicine · 2025Article
- Rediscovering the human thymus through cutting-edge technologies.The Journal of experimental medicine · 2024Review
- Human Autosomal Recessive DNA Polymerase Delta 3 Deficiency Presenting as Omenn Syndrome.Journal of clinical immunology · 2023Article
- Downregulation of Krüppel-like factor 14 accelerated cellular senescence and aging.Aging cell · 2023Article
- Prospects of POLD1 in Human Cancers: A Review.Cancers · 2023Review
- Human thymus in health and disease: Recent advances in diagnosis and biology.Seminars in immunology · 2023Review
- Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia.JCI insight · 2022Article
- Congenital Diseases of DNA Replication: Clinical Phenotypes and Molecular Mechanisms.International journal of molecular sciences · 2021Review
- Mechanisms of Genome Maintenance in Plants: Playing It Safe With Breaks and Bumps.Frontiers in genetics · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Diana X Nichols-Vinueza *Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 5-3950, 10 Center Dr, Bethesda, MD, 20892, USA.
Ottavia M Delmonte *Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 5-3950, 10 Center Dr, Bethesda, MD, 20892, USA.
Vanessa BundyDivision of Allergy and Immunology, Children's National Hospital, Washington, D.C, USA.
Marita BosticardoLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 5-3950, 10 Center Dr, Bethesda, MD, 20892, USA.
Michael T ZimmermannGenomic Sciences and Precision Medicine Center, Medical College Wisconsin, Milwaukee, WI, USA.
Nikita R DsouzaGenomic Sciences and Precision Medicine Center, Medical College Wisconsin, Milwaukee, WI, USA.
Francesca PalaLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 5-3950, 10 Center Dr, Bethesda, MD, 20892, USA.
Kerry DobbsLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 5-3950, 10 Center Dr, Bethesda, MD, 20892, USA.
Jennifer StoddardDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Julie E NiemelaDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Hye Sun KuehnDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Michael D KellerDivision of Allergy and Immunology, Children's National Hospital, Washington, D.C, USA.
Cesar M RuedaDepartment of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Roshini S AbrahamDepartment of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Raul UrrutiaGenomic Sciences and Precision Medicine Center, Medical College Wisconsin, Milwaukee, WI, USA.
Sergio D RosenzweigDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 5-3950, 10 Center Dr, Bethesda, MD, 20892, USA. luigi.notarangelo2@nih.gov.ORCID 0000-0002-8335-0262
Funding
Characterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2MZINC FINGER GENES AND PANCREATIC CELL GROWTHR01DK052913 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI LOMBERK, GWEN, URRUTIA, RAUL A. · 1998 to 2023
$7.0MMutation Analysis Of Selected Lymphoid Immune DisordersZIACL010304 · CLC · CLINICAL CENTER · PI ROSENZWEIG, SERGIO · 2009 to 2025
$0kIntramural NIH HHS ZIA AI001222NIDDK NIH HHS R01 DK052913
Abstract
PubMed holds no abstract for this paper.
Indexed as
DNA RepairBiomarkersB-LymphocytesCell DifferentiationChildConsanguinityDNA Polymerase IIIGenetic Association StudiesGenetic Predisposition to DiseaseHomozygoteHumansLymphopoiesisMaleMutation, MissensePedigreePhenotypeBiomarkersDNA Polymerase IIIPOLD1 protein, human
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.