Evidence map›Paper›PMID 33140180›Full record

ReviewIntensive care medicine2020

Extracorporeal life support for adults with acute respiratory distress syndrome.

Alain Combes, Matthieu Schmidt, Carol L Hodgson, Eddy Fan, Niall D Ferguson, John F Fraser, Samir Jaber, Antonio Pesenti, Marco Ranieri, Kathryn Rowan and 3 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Intensive care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 3 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 3 syntheses or guidelines pooled it, 217 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Observational
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. "High blood flow" versus "low blood flow" ECCOCritical care (London, England) · 2025
    Article
  18. The Driving Pressure Setting of Acute Respiratory Distress Syndrome: Beyond the Age.American journal of respiratory and critical care medicine · 2025
    Article
  19. Review
  20. The role of extracorporeal COFrontiers in medicine · 2025
    Review

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 6 countries.

Alain CombesSorbonne Université, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, 75013, Paris, France. alain.combes@aphp.fr.ORCID 0000-0002-6030-3957
Matthieu SchmidtSorbonne Université, INSERM, UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, 75013, Paris, France.
Carol L HodgsonAustralian and New Zealand Intensive Care-Research Centre, Monash University, Melbourne, Australia.
Eddy FanInterdepartmenal Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Niall D FergusonDepartment of Medicine, Division of Respirology, University Health Network, Toronto, ON, Canada.
John F FraserCritical Care Research Group, Adult Intensive Care Services, Northside Medical School, The Prince Charles Hospital, University of Queensland, Brisbane, Australia.
Samir JaberInstitut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), From the PhyMedExp, University of Montpellier, Centre Hospitalier Universitaire (CHU) Montpellier, Montpellier, France.
Antonio PesentiDepartment of Anesthesia, Critical Care and Emergency, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Marco RanieriIntensive Care Unit, Policlinico di Sant'Orsola, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Kathryn RowanClinical Trials Unit, Intensive Care National Audit and Research Centre (ICNARC), London, UK.
Kiran ShekarAdult Intensive Care Services, Critical Care Research Group, the Prince Charles Hospital, Brisbane, QLD, Australia.
Arthur S SlutskyInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
Daniel BrodieDivision of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, NewYork-Presbyterian Hospital, New York, USA.
Inserm · FRUniversity Health Network · CAAustralian and New Zealand Intensive Care Society · AUCentre National de la Recherche Scientifique · FRIntensive Care National Audit & Research Centre · GBIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITNewYork–Presbyterian Hospital · USQueensland University of Technology · AUSt. Michael's Hospital · CAThe University of Queensland · AUUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracorporeal life support (ECLS) can support gas exchange in patients with the acute respiratory distress syndrome (ARDS). During ECLS, venous blood is drained from a central vein via a cannula, pumped through a semipermeable membrane that permits diffusion of oxygen and carbon dioxide, and returned via a cannula to a central vein. Two related forms of ECLS are used. Venovenous extracorporeal membrane oxygenation (ECMO), which uses high blood flow rates to both oxygenate the blood and remove carbon dioxide, may be considered in patients with severe ARDS whose oxygenation or ventilation cannot be maintained adequately with best practice conventional mechanical ventilation and adjunctive therapies, including prone positioning. Extracorporeal carbon dioxide removal (ECCO

Indexed as

Extracorporeal Membrane OxygenationRespiratory Distress SyndromeAdultExtracorporeal CirculationHumansRespiration, ArtificialTidal VolumeAcute respiratory failureExtracorporeal membrane oxygenationMechanical ventilationOutcome

Identifiers

PMID33140180
PMCPMC7605473
OpenAlexW3096507645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.