Evidence map›Paper›PMID 33140127›Full record

ArticleAnalytical and bioanalytical chemistry2021

Exploring extra dimensions to capture saliva metabolite fingerprints from metabolically healthy and unhealthy obese patients by comprehensive two-dimensional gas chromatography featuring Tandem Ionization mass spectrometry.

Marta Cialiè Rosso, Federico Stilo, Simone Squara, Erica Liberto, Stefania Mai, Chiara Mele, Paolo Marzullo, Gianluca Aimaretti, Stephen E Reichenbach, Massimo Collino and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Characterization of volatiles in flowers from fourFrontiers in plant science · 2023
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  6. Effect of Inoculation withJournal of agricultural and food chemistry · 2022
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Marta Cialiè Rosso *Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125, Torino, Italy.
Federico Stilo *Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125, Torino, Italy.
Simone SquaraDipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125, Torino, Italy.
Erica LibertoDipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125, Torino, Italy.
Stefania MaiDivision of General Medicine, IRCCS Istituto Auxologico Italiano Ospedale S. Giuseppe, 28824, Piancavallo, Italy.
Chiara MeleDivision of General Medicine, IRCCS Istituto Auxologico Italiano Ospedale S. Giuseppe, 28824, Piancavallo, Italy.
Paolo MarzulloDivision of General Medicine, IRCCS Istituto Auxologico Italiano Ospedale S. Giuseppe, 28824, Piancavallo, Italy. paolo.marzullo@med.uniupo.it.
Gianluca AimarettiDepartment of Translational Medicine, University of Piemonte Orientale, 28100, Novara, Italy.
Stephen E ReichenbachComputer Science and Engineering Department, University of Nebraska, Lincoln, NE, 68588, USA.
Massimo CollinoDipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125, Torino, Italy.
Carlo BicchiDipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125, Torino, Italy.
Chiara CorderoDipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125, Torino, Italy. chiara.cordero@unito.it.
University of Turin · ITIRCCS Istituto Auxologico Italiano · ITOspedale San Giuseppe · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Nebraska–Lincoln · US

Funding

ERA-NET Biomarkers for Nutrition and Health Implementing the JPI HDHL objectives Project Acronym "SALIVAGES"
6 · The paper itself

Abstract

This study examines the information potential of comprehensive two-dimensional gas chromatography combined with time-of-flight mass spectrometry (GC×GC-TOF MS) and variable ionization energy (i.e., Tandem Ionization™) to study changes in saliva metabolic signatures from a small group of obese individuals. The study presents a proof of concept for an effective exploitation of the complementary nature of tandem ionization data. Samples are taken from two sub-populations of severely obese (BMI > 40 kg/m

Indexed as

AcetylglucosamineAlgorithmsAmino Acids, NeutralChromatographyChromatography, GasChromatography, High Pressure LiquidCyclohexanesDeoxyriboseEstersFuzzy LogicGas Chromatography-Mass SpectrometryGlucuronatesHumansLactoseMaleN-Acetylneuraminic Acid5-aminovaleric acidAcetylglucosamineAmino Acids, NeutralCyclohexaneCyclohexanesDeoxyriboseEstersGlucuronatesglucuronolactoneLactoseN-Acetylneuraminic AcidSolventsUreaComprehensive two-dimensional gas chromatography-time of flight mass spectrometryFused data from multiplexed ionizationSaliva metabolomeUntargeted fingerprinting by template matchingVariable ionization energy

Identifiers

PMID33140127
PMCPMC7806578
OpenAlexW3096094441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.