Trial reportPharmaceutical research2020
Simultaneous Pharmacokinetic Analysis of Nitrate and its Reduced Metabolite, Nitrite, Following Ingestion of Inorganic Nitrate in a Mixed Patient Population.
Trial report in Pharmaceutical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of dietary nitrate on human muscle power: a systematic review and individual participant data meta-analysis.Journal of the International Society of Sports Nutrition · 2021Pooled it
- Pilot randomized trial of the effect of antibacterial mouthwash on muscle contractile function in healthy young adults.PloS one · 2025Trial
- The influence of sex on the effects of inorganic nitrate supplementation on muscular power and endurance.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Trial
- The effects of inorganic nitrate supplementation on exercise economy and endurance capacity across the menstrual cycle.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Short-term beetroot juice supplementation improves muscle speed and power but does not reduce blood pressure or oxidative stress in 65-79 y old men and women.Nitric oxide : biology and chemistry · 2023Trial
- Inorganic nitrate supplementation and blood flow restricted exercise tolerance in post-menopausal women.Nitric oxide : biology and chemistry · 2022Trial
- An Integrated AIVIVE-PBPK-QIVIVE Framework with HTTK Validation for Probabilistic Risk Assessment of Neodymium Nitrate.Chemical research in toxicology · 2026Article
- Influence of exercise training on nitric oxide pathways and their physiological effects.Redox biology · 2026Review
- Decreased endogenous nitric oxide production in acute decompensated heart failure with a reduced ejection fraction.ESC heart failure · 2025Article
- Salivary-Gland-Mediated Nitrate Recirculation as a Modulator for Cardiovascular Diseases.Biomolecules · 2025Review
- Beetroot juice supplementation and exercise performance: is there more to the story than just nitrate?Frontiers in nutrition · 2024Review
- The inorganic NItrate and eXercise performance in Heart Failure (iNIX-HF) phase II clinical trial: Rationale and study design.Contemporary clinical trials communications · 2023Article
- Markers for the Prediction of Probably Sarcopenia in Middle-Aged Individuals.Journal of personalized medicine · 2022Article
- Article
- Skeletal Muscle Contractile Function in Heart Failure With Reduced Ejection Fraction-A Focus on Nitric Oxide.Frontiers in physiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeThe pharmacokinetic properties of plasma NO
methodsLinear and non-linear mixed effects analyses were used to statistically define concentration dependency on time, dose, as well as patient and study variables, and to integrate NO
resultsA population pharmacokinetic model relating NO
conclusionsExtension of the present first-generation model, to ultimately optimize NO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.